Results 61 to 70 of about 81,502 (284)

Assessment of Driver’s Drowsiness Based on Fractal Dimensional Analysis of Sitting and Back Pressure Measurements

Frontiers in Psychology, 2018
The most effective way of preventing motor vehicle accidents caused by drowsy driving is through a better understanding of drowsiness itself. Prior research on the detection of symptoms of drowsy driving has offered insights on providing drivers with ...
Atsuo Murata, Ippei Kita, Waldemar Karwowski   +2 more
doaj   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Using Artificial Neural Network to Destroy the Process of Traffic Accident Victims in Yazd Province

Health in Emergencies & Disasters Quarterly, 2021
Background: Road accidents are among the most important causes of death and severe personal and financial injuries. Also, its profound social, cultural, and economic effects threaten human societies.
Mohammad Reza Omidi, Meysam Jafari Eskandari, Nabi Omidi   +2 more
doaj  

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

The provincial border, information costs, and stock price crash risk [PDF]

, 2022
Lidan Li, Wenbin Long, Jun Hu, Xianzhong Song   +3 more
openalex   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

A Systematic Review of GIS-Driven Road Traffic Accident Evaluation

Vehicles
The review has explored the application of Geographic Information Systems (GIS) in evaluating road traffic crashes, stressing its role in identifying crash spatial patterns and hotspots. GIS offers a framework for integrating spatial and non-spatial data,
Basha Fayissa Deressa, Kidanemariam Alula Habtegiogis, Destaw Kifile Endashaw, Baqer Muhammad Al-Ramadan, Hassan Musaed Al-Ahmadi   +4 more
doaj   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Mapping Bicycle Crash Risk Patterns on the Local Scale

Safety, 2016
Currently, mainly aggregated statistics are used for bicycle crash risk calculations. Thus, the understanding of spatial patterns at local scale levels remains vague.
Martin Loidl, Gudrun Wallentin, Robin Wendel, Bernhard Zagel   +3 more
doaj   +1 more source