Results 61 to 70 of about 42,801 (258)

Continuous Subcutaneous Apomorphine as a Temporary Bridging Therapy for Dopamine Dysregulation Syndrome in Patients with Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dopamine dysregulation syndrome (DDS) is a challenging complication of dopaminergic therapy in Parkinson's disease and can persist despite subthalamic deep brain stimulation (STN‐DBS). We evaluated a temporary bridging concept in which oral dopaminergic medication was replaced by continuous subcutaneous apomorphine infusion while ...
Tobias Binder, Johannes Hartig, Lennart Sitzmann, Chi Wang Ip, Philipp Capetian, Florian Lange, Martin Reich, Christine Daniels, Jens Volkmann   +8 more
wiley   +1 more source

Craving em usuários de crack segundo características individuais e comportamentais

Epidemiologia e Serviços de Saúde, 2019
Resumo Objetivo: analisar a variação dos níveis de craving segundo características individuais e comportamentais dos usuários de crack de dois serviços públicos de tratamento especializado em Pelotas, Rio Grande do Sul, Brasil.
Karine Langmantel Silveira, Michele Mandagará de Oliveira, Bruno Pereira Nunes, Poliana Farias Alves, Gabriela Botelho Pereira   +4 more
doaj   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Electrophysiology and Functional Magnetic Resonance Imaging of Cue Craving: Potential Biomarkers for Therapeutic Neuromodulation in Addiction

Biological Psychiatry Global Open Science
A major goal for substance use disorder (SUD) treatment is the reduction of drug craving, which contributes to continued drug use and relapse. Pathological craving is thought to reflect dysfunction in neural networks, sparking a growing interest in ...
Jody Tanabe, Jordan Hickman, Andy Tekriwal, Joseph Sakai, Aviva Abosch, Steven Ojemann, Joseph P. Schacht, John A. Thompson   +7 more
doaj   +1 more source

In quest of satisfaction

Journal of Hospital Medicine, EarlyView.
Ami Schattner
wiley   +1 more source

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

The effectiveness of transcranial photobiomodulation therapy (tPBM) and transauricular vagus nerve stimulation (taVNS) on reducing alcohol craving

Neurotherapeutics
Alcohol craving plays a central role in sustaining alcohol use and contributing to relapse. Noninvasive neuromodulation techniques such as transcranial photobiomodulation (tPBM) and transauricular vagus nerve stimulation (taVNS) may target craving ...
Manjae Kwon, Minkyung Park, Minjae Kim, Jungyoon Kang, Woo-Young Ahn, Dongil Chung, Jung-Seok Choi, Young-Chul Jung   +7 more
doaj   +1 more source

Effects of Orbitofrontal Cortex tDCS on Cognitive Control in Individuals With Obesity: A Randomized Sham‐Controlled Trial

Obesity, EarlyView.
ABSTRACT Objective Neurocognitive traits can drive obesity‐related eating behaviors. The orbitofrontal cortex (OFC) integrates reward and sensory information to guide food‐related decision‐making. Here, we build on prior data in individuals without obesity demonstrating that transcranial direct current stimulation (tDCS) of the OFC improves cognitive ...
Jessica Ruffolo, Alexander McGirr, Stephanie L. Borgland   +2 more
wiley   +1 more source

A Test of the Coase Conjecture Using Prices of Electronic Books

Southern Economic Journal, EarlyView.
ABSTRACT The Coase Conjecture predicts that a durable‐goods monopolist without commitment will rapidly cut price toward marginal cost. We test this prediction in the electronic‐book market using release‐day prices. To proxy for marginal cost, we use competitive prices of public‐domain electronic books on the same platforms.
Tim Groseclose, Alex Tabarrok
wiley   +1 more source

Development and validation of an open-source virtual reality environment for alcohol use disorder and determinants of cue-induced craving among Indian participants

Indian Journal of Psychiatry
Background: Alcohol use disorder (AUD) is a chronic relapsing illness that causes significant morbidity. Craving is a key factor responsible for relapse in AUD. Cue exposure (CE) has attempted as an assessment and therapeutic procedure in AUD.
Tamonud Modak, Sanjukta Ghosh, Abhijit R. Rozatkar   +2 more
doaj   +1 more source