Results 91 to 100 of about 361,160 (313)
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Role of voluntary litter consumption by broiler chickens on gut function and gut health
, 2012 Poultry housed in floor pen systems are able and likely to consume litter materials from the floor. How consumption of different types of litter materials affects growth performance, nutrient digestibility, gut function and gut health in poultry is a ...
Svihus, Birger, Wu, Shubiao
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Advanced Science, EarlyView.ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang +8 more
wiley +1 more source
Advanced Science, EarlyView.AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li +6 more
wiley +1 more source
Brite innovation survey : executive summary
, 2005 This report summarises the fi ndings of an innovation survey\ud of the Australian construction industry undertaken by the\ud BRITE Project of the CRC for Construction Innovation in\ud 2004.
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Advanced Science, EarlyView.This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey +6 more
wiley +1 more source
Preliminary report on data mining techniques for life prediction
, 2006 This project is an extension of a previous CRC project (220-059-B) which developed\ud a program for life prediction of gutters in Queensland schools. A number of sources\ud of information on service life of metallic building components were formed into ...
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Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation
Advanced Science, EarlyView.An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng +10 more
wiley +1 more source
Journal of Biomedical ScienceBackground Animal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to sleep variability in humans is not yet established.
Nasrin Mortazavi +17 more
doaj +1 more source
Report on the Development and Validation of the Best Practice Decision Matrix
, 2001 The Co-operative Research Centre for Construction Innovation (CRC-CI) is funding a project known as Value Alignment Process for Project Delivery. The project consists of a study of best practice project delivery and the development of a suite of products,
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