Results 51 to 60 of about 1,107,300 (284)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance. [PDF]

, 2014
BACKGROUND: Colorectal cancer (CRC) progression is associated with suppression of host cell-mediated immunity and local immune escape mechanisms. Our aim was to assess the immune function in terms of expression of TNF, IFNG and FOXP3 in CRC. METHODS:
A D Beggs, A Merlo, AG Heriot, AM Wolf, C Evans, C Grunfeld, C Loddenkemper, CF Evans, D Kumar, DJ Needham, E Sato, F Balkwill, G Brandacher, G Galizia, G Pawelec, H Nakayama, IC Talbot, JC Harrison, JD Fontenot, JK Polansky, KE Sullivan, KJ Livak, KL Ling, L Xue, LA Liotta, LM Ebert, M Kanazawa, M Kim, M Morris, M Shibata, N Hiraoka, N Kobayashi, N Watanabe, P Quirke, P Radhakrishnan, P Salama, PJ Coffer, R Somasundaram, RJ O’Hara, S Hinz, S Hori, S K Ganapathi, S Ogino, S V Hodgson, SL Clarke, SM Phillips, T Blankenstein, T Sato, TJ Curiel, TJ Curiel, VC Petersen, W Zou, X Chen   +52 more
core   +2 more sources

Circ_0007031 Serves as a Sponge of miR-760 to Regulate the Growth and Chemoradiotherapy Resistance of Colorectal Cancer via Regulating DCP1A

Cancer Management and Research, 2020
Yuanyuan Wang,1,2,* Hua Wang,3,* Jian Zhang,2 Zhifen Chu,2 Pu Liu,2 Xing Zhang,2 Chao Li,2 Xiaosong Gu1 1Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, People’s Republic of China; 2Department of General ...
Wang Y, Wang H, Zhang J, Chu Z, Liu P, Zhang X, Li C, Gu X   +7 more
doaj  

OTOP2, Inversely Modulated by miR-3148, Inhibits CRC Cell Migration, Proliferation and Epithelial–Mesenchymal Transition: Evidence from Bioinformatics Data Mining and Experimental Verification

Cancer Management and Research, 2022
Shuai Guo, Yang Sun Division of No.2 Gastrointestinal Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of ChinaCorrespondence: Yang Sun, Tel +86-17709872003, Email sunyangdavid@
Guo S, Sun Y
doaj  

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. [PDF]

, 2016
Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of
Aguado, Andrea, Anant, Shrikant, Blanco, Fernando F., Brody, Jonathan R., Dixon, Dan A., Meisner-Kober, Nicole, Padhye, Subhash, Preet, Ranjan, Stevens, Laura E., Vishwakarma, Vikalp, Vyas, Alok, Weir, Scott J., Xu, Liang   +12 more
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Critical care provision after colorectal cancer surgery [PDF]

, 2016
Background: Colorectal cancer (CRC) is the 2nd largest cause of cancer related mortality in the UK with 40 000 new patients being diagnosed each year. Complications of CRC surgery can occur in the perioperative period that leads to the requirement of ...
Dale, C.D., Kinsella, J., McLoone, P., Morrison, D., Puxty, K., Quasim, T., Sloan, B.   +6 more
core   +1 more source

Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI

npj Parkinson's Disease, 2021
Parkinson’s disease (PD) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (NM)-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN).
Frédérique Depierreux, Eric Parmentier, Laurane Mackels, Katherine Baquero, Christian Degueldre, Evelyne Balteau, Eric Salmon, Christophe Phillips, Mohamed Ali Bahri, Pierre Maquet, Gaëtan Garraux   +10 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source