Results 261 to 270 of about 1,704,829 (382)

Microfluidic Biochip‐Based Multiplexed Profiling of Small Extracellular Vesicles Proteins Integrated with Machine Learning for Early Disease Diagnosis

Advanced Science, EarlyView.
This study develops a diagnostic platform for early detection of esophageal squamous cell carcinoma (ESCC) by integrating a barcode immunoassay biochip with machine learning. The biochip captures and analyzes small extracellular vesicle proteins from serum samples, identifying nine biomarkers linked to ESCC.
Xue Zhang, Yibin Jia, Zhikai Li, Yunhong Zhang, Chao Wang, Yanbo Liang, Jiaoyan Qiu, Mingyuan Sun, Xiaoshuang Chen, Miao Huang, Yu Zhang, Jianbo Wang, Hong Liu, Chuanbin Mao, Lin Han   +14 more
wiley   +1 more source

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Advanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au   +16 more
wiley   +1 more source

Baseline Estimates of Colorectal Cancer Screening Among Adults Aged 45 to 75 Years, Behavioral Risk Factor Surveillance System, 2022. [PDF]

Prev Chronic Dis
King SC, King J, Thomas CC, Richardson LC.   +3 more
europepmc   +1 more source

ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling

Advanced Science, EarlyView.
In this study, ferroptosis in colorectal cancer cells is induced by FK866 through the NAD⁺/STAT3/GPX4 pathway. To minimize systemic toxicity, a reactive oxygen species (ROS)‐responsive hydrogel is developed to co‐deliver FK866 and C188‐9, resulting in synergistic and localized antitumor effects.
Chenyang Ye, Mi Mi, Saimeng Shi, Lina Qi, Shanshan Weng, Lu Wang, Yier Lu, Chao Chen, Yinuo Tan, Mengyuan Yang, Cheng Guo, Rui Bai, Xuefeng Fang, Ji Wang, Ying Yuan   +14 more
wiley   +1 more source

710 Risk of Advanced Proximal Neoplasia (APN) Among 10,124 Index Screening Colonoscopies: Implications for Colorectal Cancer (CRC) Screening

, 2009
Thomas F. Imperiale, Elizabeth A. Glowinski, Ching Lin-Cooper, Brian J. Linder, Kristine Courtney, David F. Ransohoff   +5 more
openalex   +1 more source

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

Advanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo, Xiaoli Jin, Lan Huang, Dejia Zeng, Nan Zhang, Shiyu Tang, Shu Luo, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Shufang Liang   +10 more
wiley   +1 more source

A preliminary assessment of a stool-based microRNA profile for early colorectal cancer screening. [PDF]

Sci Rep
Santos DAR, Eiras M, Gonzalez-Santos M, Santos M, Pereira C, Santos LL, Dinis-Ribeiro M, Lima L.   +7 more
europepmc   +1 more source

Investigating FIT kit completion for CRC screening in younger adults in rural areas

Cheryl L. Beseler, Jungyoon Kim, Melissa Leypoldt, Roma Subramanian, Tamara Robinson, Karen Funkenbusch, Jason M. Foster, Susan J. Harris, Aaron Yoder, Emma Hymel, Shinobu Watanabe‐Galloway   +10 more
openalex   +1 more source

Does Screening Colonoscopy at an Earlier Age in Asymptomatic Patients With Family History of Colorectal Cancer (CRC) Improve Polyp and Colon Cancer Detection Rate?

, 2011
Naeem Aslam, Marc F. Catalano, Robbie Taha, Nalini M. Guda, Joseph E. Geenen   +4 more
openalex   +1 more source