Results 71 to 80 of about 214,860 (278)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Patient Understanding of Benefits, Risks, and Alternatives to Screening Colonoscopy [PDF]

, 2013
While several tests and strategies are recommended for colorectal cancer (CRC) screening, studies suggest that primary care providers often recommend colonoscopy without providing information about its risks or alternatives.
Barrett, Patrick R., Edenberg, Elizabeth, Imperiale, Thomas F., Meslin, Eric M., Perkins, Susan M., Schwartz, Peter H.   +5 more
core   +1 more source

Persuasive health educational materials for colorectal cancer screening [PDF]

, 2014
This paper describes an effort to design and evaluate persuasive educational materials for colorectal cancer (CRC) screening. Although CRC screening is highly effective, screening rates in the US remain low.
Arbuckle, Nicole B., Borders, Morgan R., Doebbeling, Bradley N., Flanagan, Mindy E., Hall, Nathan P., Militello, Laura G., Saleem, Jason J.   +6 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The Dutch public are positive about the colorectal cancer-screening programme, but is this a well-informed opinion?

BMC Public Health, 2016
Background Population-based colorectal cancer (CRC) screening is widely recommended, and members of the eligible screening population seem to be positive about it.
Linda N. Douma, Ellen Uiters, Danielle R. M. Timmermans   +2 more
doaj   +1 more source

“Sorry for laughing, but it’s scary”: humor and silence in discussions of Colorectal Cancer with Urban American Indians

BMC Cancer, 2023
Background Given high rates of cancer mortality in Native communities, we examined how urban American Indian and Alaska Native elders talk about colorectal cancer (CRC) and CRC screening.
Dedra S. Buchwald, Deborah R. Bassett, Emily R. Van Dyke, Raymond M. Harris, Jessica D. Hanson, Shin-Ping Tu   +5 more
doaj   +1 more source

Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation [PDF]

, 2017
This is the final version of the article. Available from the publisher via the DOI in this record.BACKGROUND: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC ...
Aarnio, Ahadova, Arends, Balmana, Barnetson, Barrow, Barrow, Barrow, Barzi, Boland, Bonadona, Bonis, Bouzourene, Bowel Cancer UK, Burn, Cairns, Caldes, Calvert, Cancer Research, Cancer Research UK, Cancer Research UK, Centre for Reviews and Dissemination, Chang, Chen, Colling, Commercial Medicines Unit, Curtis, Curtis, Cuzick, de Boer, Department of Health, Desouza, Dietmaier, Dineen, Dinh, Doble, Dolan, Domingo, Dove-Edwin, Drummond, East of Scotland Regional Genetic Service, Eccleston, Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group, Evers, Fajobi, Ferrandina, Finan, Frayling, Färkkilä, Gallego, Gallego, Gallego, Gavin, George, Giardiello, Goker, Goldstein, Great Britain, Grosse, Haanstra, Hall, Hampel, Hampel, Hanly, Haraldsdottir, Haraldsdottir, Havrilesky, Hendriks, Hildebrandt, Hornbrook, Hung, Ibrahim, Janus, Jenkins, John, Joint Formulary Committee, Järvinen, Järvinen, Kalady, Kaur, Kempers, Kloor, Kuppermann, Labianca, Ladabaum, Ladabaum, Le, Lewin, Ligtenberg, Lijmer, Limburg, Lin, Longworth, Loughrey, Lynch, Maeda, Mecklin, Mhaidat, Mittmann, Moher, Morak, Mueller, Mulder, Munoz, Mvundura, Møller, Møller, National Cancer Intelligence Network, National Cancer Intelligence Network, National Comprehensive Cancer Network, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, Ness, Newton, NHS, NHS Prescription Services, Niessen, Niv, Nout, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Okkels, Overbeek, Overbeek, Palomaki, Pande, Parsons, Pawlik, Peninsula Technology Assessment Group (PenTAG), Philips, Pollett, Poulogiannis, Poynter, Ramsey, Ramsey, Ransohoff, Renkonen-Sinisalo, Sacco, Schmeler, Schnell, Senter, Severin, Sharp, Shia, Shlien, Sjursen, Sjursen, Slade, Snowsill, Snowsill, Southey, Stein, Sundar, The Stationery Office, Thompson, Thong, Trueman, UK Genetic Testing Network, Umar, US National Library of Medicine, Vasen, Vasen, Vasen, Vasen, Veysey, Wang, Ward, Webber, Welsh Cancer Intelligence and Surveillance Unit, Whiting, Whiting, Whiting, Wong, Wong, Wong, Zhang   +193 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Need for Office Systems to Improve Colorectal Cancer Screening

Journal of Primary Care & Community Health, 2012
Patients generally access colorectal cancer (CRC) screening through primary care physicians. National guidelines recommend CRC screening for adults beginning at age 50, yet one-third of Americans are not up to date.
Barcey T. Levy, Jeanette M. Daly, Erin J. Schmidt, Yinghui Xu   +3 more
doaj   +1 more source

Appearances of screen-detected versus symptomatic colorectal cancers at CT colonography. [PDF]

, 2016
OBJECTIVES: The aim of this study was to compare the morphology, radiological stage, conspicuity, and computer-assisted detection (CAD) characteristics of colorectal cancers (CRC) detected by computed tomographic colonography (CTC) in screening and ...
Atkin, WS, Burling, D, Halligan, S, Nickerson, C, Pathiraja, F, Plumb, AA, Taylor, SA, Wooldrage, K   +7 more
core   +3 more sources