Results 81 to 90 of about 1,704,829 (382)

Effectiveness of a Mailed Colorectal Cancer Screening Outreach Program in Community Health Clinics: The STOP CRC Cluster Randomized Clinical Trial

JAMA Internal Medicine, 2018
Importance Approximately 24 million US individuals receive care at federally qualified health centers, which historically have low rates of colorectal cancer screening.
G. Coronado, Amanda F. Petrik, W. Vollmer, S. Taplin, Erin M. Keast, S. Fields, B. Green   +6 more
semanticscholar   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Risk of advanced colorectal neoplasia according to age and gender. [PDF]

, 2011
Colorectal cancer (CRC) is one of the leading causes of cancer related morbidity and death. Despite the fact that the mean age at diagnosis of CRC is lower in men, screening by colonoscopy or fecal occult blood test (FOBT) is initiated at same age in ...
Crispin, Alexander, Göke, Burkhard, Kolligs, Frank T., Mansmann, Ulrich, Munte, Axel, Wagner, Andreas   +5 more
core   +5 more sources

“Sorry for laughing, but it’s scary”: humor and silence in discussions of Colorectal Cancer with Urban American Indians

BMC Cancer, 2023
Background Given high rates of cancer mortality in Native communities, we examined how urban American Indian and Alaska Native elders talk about colorectal cancer (CRC) and CRC screening.
Dedra S. Buchwald, Deborah R. Bassett, Emily R. Van Dyke, Raymond M. Harris, Jessica D. Hanson, Shin-Ping Tu   +5 more
doaj   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Examining the relationship between household wealth and colorectal cancer screening behaviors among U.S. men aged 45–75

SSM: Population Health, 2022
Colorectal cancer (CRC) is the third leading cause of cancer-related death among men in the United States (U.S.), particularly among men aged 45 years and older.
Kevin M. Korous, Adolfo G. Cuevas, Jad Chahoud, Uchenna C. Ogbonnaya, Ellen Brooks, Charles R. Rogers   +5 more
doaj  

CRC: zuverlässiges Screening auf MMR-Defizienz [PDF]

Im Focus Onkologie, 2016
Bei den meisten Patienten mit kolorektalen Karzinomen (CRC) wird empfohlen, ein Lynch-Syndrom-Screening durchzufuhren. Bei metastasiertem CRC mussen fur die Wahl der richtigen Therapie zudem der RAS- und BRAF-Status bestimmt werden. Mithilfe des „next generation sequencing“ (NGS) kann dies in einem Schritt erfolgen.
openaire   +2 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Hospital-based Survey on Knowledge and Attitude Toward Colorectal Cancer Screening Among Indonesian Population [PDF]

, 2009
Background: Several western countries have recommended colorectal cancer (CRC) screening, however the yield of CRC screening is still low. The acceptability of CRC screening is influenced by people\u27s knowledge and attitude. This study was conducted to
Abdullah, M. (Murdani), Fauzi, A. (Achmad), Makmun, D. (Dadang), Manan, C. (Chudahman), Rani, A. A. (Abdul), Simadibrata, M. (Marcellus), Sung, J. J. (Joseph), Syam, A. F. (Ari)   +7 more
core  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source