British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Alcohol abuse and affective disorders are severe comorbid psychiatric diseases characterized by impaired brain synaptic transmission. The role of presynaptic scaffolding proteins coordinating presynaptic plasticity and neurotransmitter release, such as Bassoon (Bsn), in the pathogenesis of these disorders remains elusive.
Liubov S. Kalinichenko +14 more
wiley +1 more source
Generation and Characterization of a Transgenic Mouse That Specifically Expresses the Cre Recombinase in Spermatids. [PDF]
Genes (Basel), 2023 Gobé C +3 more
europepmc +1 more source
Cancer Science, EarlyView.Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa +7 more
wiley +1 more source
SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis
Cell Proliferation, EarlyView.The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu +16 more
wiley +1 more source
Generation of a novel Stra8-driven Cre recombinase strain for use in pre-meiotic germ cells in mice†. [PDF]
Biol Reprod, 2023 Ahmed AA +4 more
europepmc +1 more source
Limited roles of the miR‐17‐92 cluster in the regulation of T‐cell apoptosis
The FEBS Journal, EarlyView.The pro‐apoptotic protein BIM shapes T‐cell survival and function, but how it is regulated remains unclear. In a mouse model lacking direct miR‐17‐92:Bim interactions, we observed a moderate reduction in Th17 CD4+ T cells. BIM levels were modestly increased in double‐positive thymocytes and naive CD8+ T cells, but this did not affect overall T‐cell ...
Katharina Hoppe +7 more
wiley +1 more source
Pax7 haploinsufficiency impairs muscle stem cell function in Cre-recombinase mice and underscores the importance of appropriate controls. [PDF]
Stem Cell Res Ther, 2023 Mademtzoglou D +3 more
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Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó +4 more
wiley +1 more source
Cre-recombinase systems for induction of neuron-specific knockout models: a guide for biomedical researchers. [PDF]
Neural Regen Res, 2023 Shcholok T, Eftekharpour E.
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VAChT‐Cre.Fast and VAChT‐Cre.Slow: Postnatal expression of Cre recombinase in somatomotor neurons with different onset [PDF]
, 2003 Hidemi Misawa +7 more
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