Results 191 to 200 of about 98,107 (317)

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil   +11 more
wiley   +1 more source

Robust activity‐dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In cortical layer (L)5 pyramidal neurons we found that mitochondria in the axon initial segment (AIS) are distributed non‐uniformly and display robust calcium (Ca2+) uptake during action potential (AP) firing. Because the AIS is the site for the initiation of APs, which are shaped by cytosolic Ca2+ levels, we hypothesized that ...
Koen Kole, Maarten H.P. Kole
wiley   +1 more source

Myh6 promoter-driven Cre recombinase excises floxed DNA fragments in a subset of male germline cells. [PDF]

open access: yesJ Mol Cell Cardiol, 2023
Sheldon C   +8 more
europepmc   +1 more source

Generation of a transgenic mouse model with chondrocyte‐specific and tamoxifen‐inducible expression of Cre recombinase [PDF]

open access: hybrid, 2007
Mo Chen   +6 more
openalex   +1 more source

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview

open access: yesAmerican Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.
ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim   +2 more
wiley   +1 more source

Inserting Cre recombinase into the Prolactin 8a2 gene for decidua-specific recombination in mice. [PDF]

open access: yesGenesis, 2022
Dickson MJ   +8 more
europepmc   +1 more source

Generation of a Novel Col8a2P2A‐CreERT2 Mouse Line Enables Targeted Genetic Manipulation of Corneal Endothelial Cells and Modeling of Endothelial Decompensation

open access: yesgenesis, Volume 64, Issue 2, April 2026.
ABSTRACT The corneal endothelium is a monolayer of specialized cells that maintains stromal deturgescence and transparency, functions essential for vision. Despite its clinical importance, the developmental origins and homeostatic programs of the endothelium remain poorly understood, in part due to the lack of a lineage‐specific genetic driver.
Yong Yuan   +9 more
wiley   +1 more source

In Vivo Intra-Uterine Delivery of TAT-Fused Cre Recombinase and CRISPR/Cas9 Editing System in Mice Unveil Histopathology of Pten/p53-Deficient Endometrial Cancers. [PDF]

open access: yesAdv Sci (Weinh), 2023
Navaridas R   +11 more
europepmc   +1 more source

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