Results 261 to 270 of about 98,107 (317)

Site-directed integration of the cre gene mediated by Cre recombinase using a combination of mutant lox sites [PDF]

, 2002
Koji Araki
openalex   +1 more source

Prostaglandin D2 Synthase Controls Schwann Cells Metabolism and Peripheral Myelin Homeostasis

Glia, Volume 74, Issue 3, March 2026.
Prostaglandin D2 Synthase (L‐PGDS) controls PPNS myelin lipids’ composition and Schwann cells energetic metabolism In the absence of L‐PGDS Schwann cells turn to acetate as the main energetic source. These metabolic changes result in ketone bodies production to preserve neuronal survival.
Amelia Trimarco, Matteo Audano, Rosa La Marca, Marta Pellegatta, Paolo Canevazzi, Mariaconcetta Cariello, Marta Falco, Silvia Pedretti, Gabriele Imperato, Alessandro Cestaro, Paola Podini, Giorgia Dina, Angelo Quattrini, Luca Massimino, Donatella Caruso, Nico Mitro, Carla Taveggia   +16 more
wiley   +1 more source

Cre recombinase promotes leukemogenesis in the presence of both homozygous and heterozygous FLT3-ITD. [PDF]

Leukemia
Yang M, Ma Z, Wang C, Agca MC, Liu H, Huang K, Glage S, Rumpel R, Gerbaulet A, Roers A, Liu X, Noyan F, von Neuhoff N, Ganser A, Liu L, Yun H, Li Z.   +16 more
europepmc   +1 more source

Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells [PDF]

, 2006
Lionel M.L. Chow, Yong Tian, Thomas Weber, Mary K. Corbett, Jianping Zuo, Suzanne J. Baker   +5 more
openalex   +1 more source

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

Generation of a new Paneth cell-specific <i>Cre</i>-recombinase transgenic mouse line. [PDF]

Front Immunol
Garcia-Gonzalez N, Wallaeys C, Toussaint W, Hochepied T, Dewaele S, De Beul S, Van Loke R, Vandewalle J, Timmermans S, Blumberg RS, Libert C.   +10 more
europepmc   +1 more source

Development of a Live‐Cell Imaging Assay to Elucidate Spatiotemporal Dynamics of Extracellular Vesicle Fusion with Target Cells

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
We present a novel live‐cell imaging assay for detection of extracellular vesicle (EV)‐binding, ‐uptake, and ‐fusion in time and space. Using EVs carrying the fusogen VSV‐G, we demonstrate real‐time imaging of EV‐fusion, quantification of fusion kinetics and efficiency, and subcellular localization of fusion events.
Jasper van den Ende, Kyra A. Y. Defourny, Huib H. Rabouw, Marvin E. Tanenbaum, Richard W. Wubbolts, Esther N. M. Nolte‐‘t Hoen   +5 more
wiley   +1 more source

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

The Journal of Pathology, Volume 268, Issue 3, Page 249-262, March 2026.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis, Georgia Sotiropoulou   +3 more
wiley   +1 more source

A Novel Method for Floxed Gene Manipulation Using TAT-Cre Recombinase in Ex Vivo Precision-Cut Lung Slices (PCLS). [PDF]

Bio Protoc
Cheong SS, Luis TC, Hind M, Dean CH.
europepmc   +1 more source

Silencing of the Metabolic Gene HKDC1 Is Associated With Aging and Neurodegeneration in Mice and Humans

Aging Cell, Volume 25, Issue 3, March 2026.
Model showing decline in HKDC1 gene expression with aging. In a young cell, TFEB gets recruited to its binding sites on the HKDC1 promoter to upregulate HKDC1 expression, which interacts with mitochondria and stabilizes PINK1 to maintain mitochondrial health.
Zeenat Farooq, Vladimir Ilievski, James Boyett, Julianne Jorgensen, Yang Pan, Tanika Kelly, David Bennett, Orly Lazarov, Brian T. Layden   +8 more
wiley   +1 more source