Results 271 to 280 of about 98,107 (317)

The Adiponectin‐PP2A Pathway Confers Cognitive Benefits of Physical Exercise Against Chronic Stress‐Induced Tau Hyperphosphorylation in the Hippocampus

Aging Cell, Volume 25, Issue 3, March 2026.
Physical exercise ameliorates cognitive deficits and attenuates Tau hyperphosphorylation under chronic stress by elevating circulating adiponectin levels. Upon receptor binding, adiponectin modulates the LCMT1/PME‐1 regulatory axis to promote PP2A methylation and catalytic function.
Hui‐Hui Guo, Hai‐Ning Ou, Jia‐Sui Yu, Zi‐Rui Luo, Suk‐Yu Yau, Hector Wing‐Hong Tsang   +5 more
wiley   +1 more source

A Novel Cre Recombinase Mouse Strain for Cell-Specific Deletion of Floxed Genes in Ribbon Synapse-Forming Retinal Neurons. [PDF]

Int J Mol Sci
Suiwal S, Wartenberg P, Boehm U, Schmitz F, Schwarz K.   +4 more
europepmc   +1 more source

Meflin/ISLR is a meningeal cell‐specific marker involved in the development of meninges and meningioma progression

Brain Pathology, Volume 36, Issue 2, March 2026.
Mesenchymal stromal cell‐and fibroblast‐expressing Linx paralogue (Meflin) is expressed in embryonic meninges and contributes to meningeal homeostasis. In meningiomas, elevated Meflin correlates with higher grade and recurrence. Single‐cell RNA sequencing revealed a Meflin‐high tumor cell subset marked by reduced proliferation, WNT6 expression, and ...
Yukihiro Shiraki, Tomotsugu Kurauchi, Akitoshi Hara, Nobutoshi Esaki, Shinji Mii, Ryota Ando, Akihiro Sakai, Kuniaki Tanahashi, Fumiharu Ohka, Ryuta Saito, Atsushi Natsume, Yuki Hattori, Takaki Miyata, Atsushi Enomoto   +13 more
wiley   +1 more source

Bacteriophage P1 site-specific recombination. Purification and properties of the Cre recombinase protein.

, 1984
Ken Abremski, R H Hoess
openalex   +1 more source

Decision letter: A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch

, 2020

openalex   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Transcription Factor TCF12‐Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation

Cell Proliferation, Volume 59, Issue 3, March 2026.
Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao, Chi Zhang, Zuo‐Qi Deng, Yue‐xin Qiu, Zhao Zhang, Heng‐Yu Fan, Jing Li, Hong‐Bo Wu   +7 more
wiley   +1 more source

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, Volume 293, Issue 5, Page 1459-1477, March 2026.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

Foxg1 Defines Ventrolateral Zonal Identity by Sustaining Neurogenic Progenitor Potential in the Olfactory Epithelium

Genes to Cells, Volume 31, Issue 2, March 2026.
Foxg1 maintains neurogenic progenitor potential in the ventrolateral olfactory epithelium. In control (Foxg1‐cHET) embryos, Foxg1‐expressing progenitors preferentially generate olfactory sensory neurons (OSNs) and support V‐zone expansion. Conditional Foxg1 deletion (Foxg1‐cKO) reduces V‐zone growth and shifts progenitor fate toward sustentacular cells
Anzu Kuriyama, Yuta Furusho, Carina Hanashima   +2 more
wiley   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source