Results 281 to 290 of about 98,107 (317)

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

open access: yesImmunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic   +2 more
wiley   +1 more source

Uncovering Hidden Phenotypes in NEX‐Cre Mice: Behavioral and Cellular Alterations Demand Re‐Evaluation of a Widely Used Transgenic Line

open access: yesJournal of Neurochemistry, Volume 170, Issue 3, March 2026.
Cre‐driver mouse lines are widely used for targeted gene manipulation, yet their baseline phenotypes are often assumed to be neutral. Here, we reveal hidden behavioral and synaptic alterations in the commonly used NEX‐Cre line, including changes in locomotion, anxiety‐like behavior, reward‐related behavior, and region‐specific dendritic spine density ...
Kim Renken, Olivia Andrea Masseck
wiley   +1 more source

A High‐Resolution Transcriptomic Atlas of Cell Types in the Ventral Visual Thalamus

open access: yesJournal of Neurochemistry, Volume 170, Issue 3, March 2026.
Visual information from the eyes travels from retinal ganglion cells (RGCs) to reach the brain through several relay centers. One of these centers, the ventral lateral geniculate nucleus (vLGN), is much less understood than others. In this study, we created the first detailed map of the different cell types found in the mouse vLGN.
Katelyn Stebbins   +5 more
wiley   +1 more source

Alternative Pathways of Acetylcholine Release in the Colon: Role of High‐Affinity Choline Transporters

open access: yesNeurogastroenterology &Motility, Volume 38, Issue 3, March 2026.
Mechanisms of Acetylcholine release, including typical and atypical release under neuronal blockade. Left panel illustrates the classical (quantal) cholinergic transmission and the right panel the mechanism described in the present study. High‐Affinity Choline Transporter (HCT), Acetylcholine (ACh), Acetylcholinesterase (ACE), and Tetrodotoxin (TTX ...
A. Martinez‐Daunis   +4 more
wiley   +1 more source

Transgene‐Free, Gene‐Edited Cavendish Bananas (Musa acuminata, AAA)

open access: yesPlant Biotechnology Journal, Volume 24, Issue 3, Page 1620-1634, March 2026.
ABSTRACT Global consumer acceptance of gene‐edited food crops is increasing with new breeding technologies that can modify the genome without foreign DNA integration. Here, we report an Agrobacterium‐based system for transgene‐free, gene editing of the banana cultivar, Cavendish.
Maiko Kato   +6 more
wiley   +1 more source

Controlling GRF4‐GIF1 expression for efficient, genotype‐independent transformation across wheat cultivars

open access: yesThe Plant Journal, Volume 125, Issue 6, March 2026.
SUMMARY Wheat is a staple crop critical for global food security, and its continuous genetic improvement is essential to meet the demands of a growing population. Efficient, genotype‐independent transformation is a major bottleneck in wheat functional genomics and gene editing.
Sadiye Hayta   +8 more
wiley   +1 more source
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Cre Recombinase and Other Tyrosine Recombinases

Chemical Reviews, 2016
Tyrosine-type site-specific recombinases (T-SSRs) have opened new avenues for the predictable modification of genomes as they enable precise genome editing in heterologous hosts. These enzymes are ubiquitous in eubacteria, prevalent in archaea and temperate phages, present in certain yeast strains, but barely found in higher eukaryotes.
Gretchen, Meinke   +4 more
openaire   +2 more sources

Safety Assessment of Cre Recombinase

Journal of Agricultural and Food Chemistry, 2006
Cre recombinase, when used as a tool in agricultural biotechnology, can precisely excise DNA sequences that may be useful in the introduction of a new trait but are not needed in the commercial product. Although the cre genetic material would not be present in the final product, the present studies were performed to assess the safety of Cre recombinase
Ronald E, Hileman   +4 more
openaire   +2 more sources

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