Results 31 to 40 of about 98,107 (317)
SPC-Cre-ERT2 transgenic mouse for temporal gene deletion in alveolar epithelial cells. [PDF]
PLoS ONE, 2012 Although several Cre-loxP-based gene knockout mouse models have been generated for the study of gene function in alveolar epithelia in the lung, their applications are still limited.
Yao-Song Gui +7 more
doaj +1 more source
Whole-Mount X-Gal Staining of Mouse Tissues [PDF]
, 2018 Although the development of improved mouse models, including conditional deletions, marks an exciting time in mouse genetics, it is important to characterize and validate these models.
Gierut, J. J. +2 more
core +1 more source
Spatial distribution of type II collagen gene expression in the mouse intervertebral disc
JOR Spine, 2019 Genetic tools such as the Cre‐Lox reporter system are powerful aids for tissue‐specific cell tracking. For example, it would be useful in examining intervertebral disc (IVD) cell populations in normal and diseased states.
Yulong Wei +6 more
doaj +1 more source
PLoS ONE, 2014 To study gene function in neural progenitors and radial glia of the retina and hypothalamus, we developed a Rax-CreERT2 mouse line in which a tamoxifen-inducible Cre recombinase is inserted into the endogenous Rax locus.
Thomas Pak +4 more
doaj +1 more source
RNAase III-Type Enzyme Dicer Regulates Mitochondrial Fatty Acid Oxidative Metabolism in Cardiac Mesenchymal Stem Cells [PDF]
, 2019 Cardiac mesenchymal stem cells (C-MSC) play a key role in maintaining normal cardiac function under physiological and pathological conditions. Glycolysis and mitochondrial oxidative phosphorylation predominately account for energy production in C-MSC ...
Jin, Yue +5 more
core +1 more source
Disease Models & Mechanisms, 2015 Novel genetically engineered mouse models using the Cre-loxP or the Flp-FRT systems have generated useful reagents to manipulate the mouse genome in a temporally-regulated and tissue-specific manner. By incorporating a constitutive Cre driver line into a
Minsi Zhang, David G. Kirsch
doaj +1 more source
Lineage Tracing Mediated by Cre-Recombinase Activity [PDF]
Journal of Investigative Dermatology, 2015 INTRODUCTION Clinical research aims to unravel mechanisms leading to disease. Looking at a disease state, frequently asked questions are when and how did cells change their native behavior and how do these cells circumvent regulation by the healthy environment?
Vorhagen, Susanne +6 more
openaire +2 more sources
Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo [PDF]
, 2012 INTRODUCTION: Activation of focal adhesion kinase (FAK) is hypothesized to play an important role in the pathogenesis of human breast cancer. METHODS: To directly evaluate the role of FAK in mammary tumour progression, we have used a conditional FAK ...
AL Lark +35 more
core +1 more source
A chimeric Cre recombinase with regulated directionality [PDF]
Proceedings of the National Academy of Sciences, 2008 From bacterial viruses to humans, site-specific recombination and transposition are the major pathways for rearranging genomes on both long- and short-time scales. The site-specific pathways can be divided into 2 groups based on whether they are stochastic or regulated.
David, Warren +2 more
openaire +2 more sources
Cre Stoplight: A Red/Green Fluorescent Reporter of Cre Recombinase Expression in Living Cells
BioTechniques, 2001 The Cre/lox system is a powerful genetic tool with which to manipulate the genome. Here, we describe the development of a simple reporter system for Cre recombinase, called the Cre Stoplight.
Yvonne S. Yang, Thomas E. Hughes
doaj +1 more source