Results 111 to 120 of about 41,095 (303)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Most Holy Trinity as the Foundation of the Identity of Created Persons
, 2013 According to Scripture God created human beings "in our image, after our likeness". The likeness used to be conceived in terms of the rational nature human beings possess.
HANKE JAROŠOVÁ, Světla
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The rights of animals as sentient beings in Colombia
En Colombia, las normas referentes a los animales se crearon bajo la Constitución Política colombiana de 1886 y los consideraban como objetos semovientes desde principios liberales clásicos. Así, quien ostentara derechos reales sobre los animales, podría
Perilla Granados, Juan Sebastián Alejandro
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 2005 The problem domain of the investigation presented in this dissertation is knowledge increase. In particular the research is concerned with the process of knowledge increase.
Baracskai, Z. +3 more
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The impact of respect for human beings on Islamic law
, 2023 Yüksek Lisans Teziİnsan kerem sıfatına sahip bir şekilde yaratılmış olup diğer canlılardan üstün tutulmuştur. Keramet; din, ırk, mezhep vb. ayrım yapılmaksızın insanın sadece insan olmasından kaynaklanan, ortadan kalkması düşünülemeyen ve tüm insanlarda ...
Çetiner, Necmettin Nuri
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