Results 151 to 160 of about 774,651 (293)

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

Rhabdomyolysis presenting as abdominal pain: importance of early creatine kinase testing. [PDF]

Ann Med Surg (Lond)
Khatri PK, Sharma D, Gautam K.
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Enteric Fever Presenting With Acute Bilateral Lower Limb Weakness due to Para Infectious Myopathy With Elevated Serum Creatine Kinase: A Case Report. [PDF]

Clin Case Rep
Khan S, Farooq T, Hussain SF, Rehan R, Usman K, Iftikhar H, Siddiqui HH, Kamal M, Khan H, Sikandar A, Ahmed S.   +10 more
europepmc   +1 more source

Aspartate aminotransferase at large—A case of disappearing macro‐aspartate aminotransferase in a child

JPGN Reports, EarlyView.
Aaron Weston, Megan Rodney, Chris Florkowski, Linda Pike, Chris Sies, Simon Thompson, Richard King, Andrew S. Day   +7 more
wiley   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Creatine Kinase as a Potential Diagnostic Biomarker for Distinguishing Placenta Accreta Spectrum and Placenta Previa: A Prospective Pilot Study. [PDF]

J Obstet Gynaecol Res
Wang L, Liu T, Yang L, Xiao X, Chen J, Wang L.   +5 more
europepmc   +1 more source

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

Effects of CytoSorb^® hemoadsorption therapy on serum myoglobin and creatine kinase levels in severe rhabdomyolysis: a systematic review and meta-analysis. [PDF]

BMC Nephrol
Reynolds A, Scharf C, Forni LG, Koo TY, Büttner S, Humbert V, Kielstein J, Kindgen-Milles D, Meiser A, Mitzner S, Molnar Z, Premuzic V, Taborda-Küpper MS, Weidhase L, Kribben A.   +14 more
europepmc   +1 more source

Bortezomib‐based chemotherapy in Chinese pediatric patients with relapsed/refractory acute lymphoblastic leukemia: A single‐center retrospective study

Pediatric Investigation, EarlyView.
Bortezomib‐based chemotherapy achieved an 88.9% remission rate in Chinese pediatric patients with relapsed/refractory B‐cell acute lymphoblastic leukemia, enabling 62.5% of responders to bridge to transplantation, while T‐cell acute lymphoblastic leukemia showed no response.
Xingyu Zhao, Jian Wang, Liping Que, Dunhua Zhou, Jianpei Fang, Luhong Xu   +5 more
wiley   +1 more source