Rheumatology &Autoimmunity, EarlyView.This figure summarizes the clinical course and immune reconstitution in a patient with anti‐synthetase syndrome (ASyS) and recurrent refractory infections. Left panel: conventional immunosuppression is associated with marked Treg deficiency and persistent infections. Middle panel: intervention with subcutaneous low‐dose interleukin (IL)−2. Right panel:
Tian Gao +8 more
wiley +1 more source
Harnessing the Folding of Antitumor Peptides for Controlled Carrier‐Free Drug Delivery
Small, EarlyView.A disulfide‐bridged stapled p53 α‐helix co‐assembled with doxorubicin into protease‐resistant nanocomplexes. Reductive intracellular conditions induced helix refolding and nanostructure disassembly, which enabled the coordinated release of the chemotherapeutic agent and anticancer peptide.
Jae Yun Lee +9 more
wiley +1 more source
Phosphorylation-Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia-Reperfusion. [PDF]
Adv Sci (Weinh)Duan C +17 more
europepmc +1 more source
Strategies for enhancing sensitivity in lateral flow assays
VIEW, EarlyView.Lateral flow assays (LFAs) are essential for cost‐effective, rapid point‐of‐care diagnostics. However, conventional colourimetric LFAs often lack the sensitivity required for low‐abundance biomarkers. This review evaluates six enhancement strategies: flow modulation, sample preconcentration, advanced reporters, chemical signal amplification, structural
Aylar Eslami Saed +3 more
wiley +1 more source
A Hyperbranched Rolling Circle Amplification Assay Using Aptamer-Hemin/G-Quadruplex Recognition for the Detection of Creatine Kinase-MB. [PDF]
ACS Meas Sci AuMirsadoughi E +4 more
europepmc +1 more source
CAAI Transactions on Intelligence Technology, EarlyView.Abstract Internet of Medical Things (IoMT) has typical advancements in the healthcare sector with rapid potential proof for decentralised communication systems that have been applied for collecting and monitoring COVID‐19 patient data. Machine Learning algorithms typically use the risk score of each patient based on risk factors, which could help ...
Chandramohan Dhasaratha +9 more
wiley +1 more source
Health check revealed elevation of creatine kinase related to hypothyroidism. [PDF]
Endocrinol Diabetes Metab Case RepLuo X, Quan Y, Luo G.
europepmc +1 more source
A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8
Brain Pathology, EarlyView.We describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Ulrika Lindgren +5 more
wiley +1 more source
Delayed Serum Creatine Kinase Elevation After Snakebite: Serial Changes and Clinical Correlates of Myotoxicity in a Korean Tertiary-Care Cohort. [PDF]
J Clin MedPark YC, Kim OH, Lee KH, Kim SJ.
europepmc +1 more source
Gut microbiota as a novel therapeutic target for eating disorders and obesity
British Journal of Pharmacology, EarlyView.The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė +5 more
wiley +1 more source