Results 191 to 200 of about 774,651 (293)

Elevated Creatine Kinase in Mucolipidosis Type IV: Investigating an Atypical Manifestation and Its Clinical Complications. [PDF]

Cureus
Alsahlawi Z, Isa HM, Ghassan L, Taha RA, Elshafey Y, Aboultaif A, Sary MW, Isa BH.   +7 more
europepmc   +1 more source

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

The FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash, Olivier Haccard, Zhen Li, Nicolas Pollet, Kathrin Marheineke   +4 more
wiley   +1 more source

Elevated Creatine Kinase as a Marker for Aggressive GI Malignancy. [PDF]

J Community Hosp Intern Med Perspect
Vasireddy R, Atarere J, Iding J, Sankineni A.   +3 more
europepmc   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Marked Asymptomatic Creatine Kinase Elevation With Preserved Renal Function Identified Through Protocol-Driven Monitoring in a Clinical Trial Participant: A Case Report. [PDF]

Cureus
Anasobi RT, Parmar T, Stewart O.
europepmc   +1 more source

Hydrothermal origin of metabolic phosphorylation

The FEBS Journal, EarlyView.
Serpentinizing hydrothermal vents are candidate sites for biochemical origins. They generate extremely reducing conditions, depositing phosphite (HPO32−) and transition metals, including palladium, in the native (zero‐valent) state. Schlikker et al.
Manon L. Schlikker, Nadja K. Hoffmann, Sabine Metzger, Jorge Moral‐Pombo, Harun Tüysüz, William F. Martin   +5 more
wiley   +1 more source

Multi-ancestry genome-wide association study of serum creatine kinase implicates myopathy genes and muscle pathways. [PDF]

EBioMedicine
Chen G, Zhao SS, Chinoy H, Lilleker JB, Liu W, Li Y, Morris AP, Lamb JA.   +7 more
europepmc   +1 more source

A randomized phase 2 trial of socrodeucitinib in moderate‐to‐severe plaque psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In moderate‐to‐severe plaque psoriasis, socrodeucitinib (6 mg/12 mg) significantly outperformed placebo at week 12: PASI 75 response rates 28.6%/72.1% vs. 7.5%. Meanwhile, socrodeucitinib illustrated a favourable safety and tolerability profile, warranting further study.
Ling Han, Songmei Geng, Yangfeng Ding, Shifa Zhang, Xiaohua Wang, Fengming Hu, Jianguo Li, Chao Ci, Yayu Hu, Rixin Chen, Jianping Zhang, Xiaoyong Zhou, Aijun Chen, Chunlei Zhang, Tiechi Lei, Yanyan Feng, Yu Wang, Zudong Meng, Yan Zhou, Mingkai Ji, Wei Liu, Yunting Wu, Qianying Chen, Siyi Wang, Jinhua Xu   +24 more
wiley   +1 more source

Idiopathic Inflammatory Myopathy With Normal Creatine Kinase Levels in an Elderly Patient: A Diagnostic Challenge. [PDF]

Cureus
Chilakuluri P, Debnath V, Barakat A, Boussios S, Sayani S.   +4 more
europepmc   +1 more source