BJPsych Open, 2021 In forensic settings, the most common indication for clozapine is treatment-resistant schizophrenia (TRS). Clozapine has also been shown to be effective in reducing hostility, aggression and violence in patients with schizophrenia and is of benefit in ...
Hein Bokern, Niels Jonker, Dan Cohen
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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy [PDF]
, 2009 Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively.
Baas, Dominique +27 more
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³¹P Saturation Transfer and Phosphocreatine Imaging in the Monkey Brain [PDF]
, 1991 ³¹P magnetic resonance imaging with chemical-shift discrimination by selective excitation has been employed to determine the phosphocreatine (PCr) distribution in the brains of three juvenile macaque monkeys.
Allman, John +4 more
core +1 more source
Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation. [PDF]
, 2019 The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasomes regulatory particle, consisting of lid
Aufderheide +42 more
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Behavioural changes are a major contributing factor in the reduction of sarcopenia in calorie-restricted ageing mice [PDF]
, 2015 Background: In rodent models, caloric restriction (CR) with maintenance of adequate micronutrient supply has been reported to increase lifespan and to reduce age-induced muscle loss (sarcopenia) during ageing.
Anker +44 more
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Regulation of T cell development and activation by creatine kinase B.
PLoS ONE, 2009 Creatine kinase catalyzes the reversible transfer of the N-phosphoryl group from phosphocreatine to ADP to generate ATP and plays a key role in highly energy-demanding processes such as muscle contraction and flagellar motility; however, its role in ...
Yafeng Zhang +4 more
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Ckmt1 is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue
Function, 2022 Within brown adipose tissue (BAT), the brain isoform of creatine kinase (CKB) has been proposed to regulate the regeneration of ADP and phosphocreatine in a futile creatine cycle (FCC) that stimulates energy expenditure. However, the presence of FCC, and
Valerie Politis-Barber +9 more
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Technical pre-analytical effects on the clinical biochemistry of Atlantic salmon (Salmo salar L.) [PDF]
, 2016 Clinical biochemistry has long been utilized in human and veterinary medicine as a vital diagnostic tool, but despite occasional studies showing its usefulness in monitoring health status in Atlantic salmon (Salmo salar L.), it has not yet been widely ...
Ashby, A. +6 more
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In Vitro Inhibition of Human Sperm Creatine Kinase by Nicotine, Cotinine and Cadmium, as a Mechanism in Smoker Men Infertility [PDF]
International Journal of Fertility and Sterility, 2008 Background Nicotine, cotinine and cadmium are harmful components of cigarettes that have an effect on human reproductive function. Although the effects of cigarette smoke on male reproductive function is characterized in several articles its mechanism of
Mohammad Ali Ghaffari +2 more
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Increased Serum Creatine Kinase [PDF]
Clinical Chemistry, 2014 A 38-year-old white male taxi driver was referred to a lipid clinic by his general practitioner for management of combined hyperlipidemia. He was a smoker with a 20 pack-year history. His father had died of myocardial infarction at age 55 years. Examination of this patient revealed a blood pressure of 136/99 mmHg and a body mass index of 29 kg/m2, with
Mehdi, Mirzazadeh +2 more
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