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Creatine kinase and creatine kinase B‐subunit in stable and unstable angina pectoris [PDF]
European Journal of Clinical Investigation, 1986 Abstract. Repetitive ischaemic episodes may have a cumulative effect leading to irreversible myocardial cell damage with enzyme release. Using plasma creatine kinase (CK) and creatine kinase B‐subunit (CK‐B) concentrations this theory has been tested in forty‐eight patients admitted with acute chest pain, but without ECG signs of acute myocardial ...
THYGESEN, K. +4 more
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International Journal of Dermatology, 2019
AbstractBackgroundIsotretinoin has been reported to elevate creatine kinase, which may lead to fatal rhabdomyolysis.ObjectiveTo review the literature and propose practice guidelines for management of elevated creatine kinase during isotretinoin therapy.FindingsPatients have intrinsic and extrinsic qualities that may synergistically work with ...
Justin W. Marson, Hilary E. Baldwin
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AbstractBackgroundIsotretinoin has been reported to elevate creatine kinase, which may lead to fatal rhabdomyolysis.ObjectiveTo review the literature and propose practice guidelines for management of elevated creatine kinase during isotretinoin therapy.FindingsPatients have intrinsic and extrinsic qualities that may synergistically work with ...
Justin W. Marson, Hilary E. Baldwin
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Structure of mitochondrial creatine kinase
Nature, 1996Creatine kinase (CK, EC 2.7.3.2), an enzyme important for energy metabolism in cells of high and fluctuating energy requirements, catalyses the reversible transfer of a phosphoryl goup from phosphocreatine to ADP. We have solved the structure of the octameric mitochondrial isoform, Mib-CK, which is located in the intermembrane compartment and along the
Fritz-Wolf, K. +3 more
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Investigating raised creatine kinase
BMJ, 2021A 76 year old man with hypercholesterolaemia is referred to the lipid clinic because of persistently raised creatine kinase activity of 1000 IU/L or above (reference range 40-320 IU/L) after trying multiple statins. He describes no significant myalgia but had some proximal muscle weakness, which is demonstrated when he stands up from a seated position ...
Anthony S. Wierzbicki, Eun Ji Kim
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Archives of Internal Medicine, 1982
To the Editor. —I read with interest the article by Dillon et al entitled "Diagnostic Problem in Acute Myocardial Infarction: CK-MB in the Absence of Abnormally Elevated Total Creatine Kinase Levels" published in the JanuaryArchives(1982;142:33-38).
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To the Editor. —I read with interest the article by Dillon et al entitled "Diagnostic Problem in Acute Myocardial Infarction: CK-MB in the Absence of Abnormally Elevated Total Creatine Kinase Levels" published in the JanuaryArchives(1982;142:33-38).
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Creatine and Creatine Kinase in Health and Disease
2007Creatine and creatine kinase in health and disease / , Creatine and creatine kinase in health and disease / , کتابخانه دیجیتال جندی شاپور ...
Gajja S. Salomons, Markus Wyss
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Interpretation of Creatine Kinase
JAMA: The Journal of the American Medical Association, 1981To the Editor.— We would like to comment on the article by C. Jack Bark, MD (1980;24:2058), in which he postulates that a creatine kinase (CK) isoenzyme migrating cathodically to the CK-MM band represents mitochondrial CK. Although it has been generally accepted that the commercially produced reagents inhibit adenylate kinase (AK) activity in CK ...
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Archives of disease in childhood - Education & practice edition, 2019
Creatine kinase (CK) remains an essential tool for assessment of muscular weakness and pain in children despite the advent of advanced diagnostic tests in this field. It is also useful in diagnosing and monitoring various other conditions. This article will explore the physiology of CK and clinical situations where the estimation of CK can help the ...
Tanmoy Chakrabarty +2 more
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Creatine kinase (CK) remains an essential tool for assessment of muscular weakness and pain in children despite the advent of advanced diagnostic tests in this field. It is also useful in diagnosing and monitoring various other conditions. This article will explore the physiology of CK and clinical situations where the estimation of CK can help the ...
Tanmoy Chakrabarty +2 more
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Elevated Creatine Kinase and Malignancy
Hospital Practice, 1990Increased serum levels of CK isoenzymes variously signal heart, brain, or skeletal muscle damage. They may also be markers for advanced tumors with poor prognosis.
Alan E. Skolnick +2 more
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Hybridization of matrix-bound MM-creatine kinase with BB-creatine kinase and arginine kinase
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1994Dimeric rabbit muscle creatine kinase (MM-CK) was bound to CNBr-activated Sepharose 4B by one of its subunits (MM-CKA). Treatment of MM-CKA with guanidine hydrochloride released the unbound subunit to yield the matrix-bound monomer (M-CKB). M-CKB recombined with dissociated MM-CK soluble subunits to reconstitute a matrix-bound dimer (MM-CKC).
S. Raghupathi Rami Reddy, David C. Watts
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