Results 51 to 60 of about 102,139 (259)
Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity
Advanced Science, EarlyView.Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten +30 more
wiley +1 more source
Advanced Science, EarlyView.USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen +7 more
wiley +1 more source
Increased postictal creatine kinase in epilepsy patients
Эпилепсия и пароксизмальные состоянияExcessive muscle activity during generalized convulsive seizures in epilepsy patients in some cases can cause significant changes in blood plasma biochemical parameters, increased level of a set of metabolites, particularly, serum creatine kinase ...
L. V. Lipatova, I. V. Sakovsky
doaj +1 more source
Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2022 Objective Optimum recovery can prevent the athlete's functional capacity from falling between training sessions or competitions. The aim of this study was to evaluate the effect of dry cupping therapy and creatine supplementation on lactic acid, lactate ...
Faiza Mohammad Qoliha +3 more
doaj
Advanced Science, EarlyView.A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang +11 more
wiley +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Impact of sepak takraw practice on inflammatory markers in male athletes [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2016 The objective of this study was to investigate the impact of sepak takraw practice on interleukin-6 and creatine kinase concentrations. Twelve male sepak takraw athletes participated in this research. A cross-over design was created consisting of sepak
Supaporn Silalertdetkul
doaj
ASN Neuro, 2014 Creatine is the substrate for creatine kinase in the synthesis of phosphocreatine (PCr). This energetic system is endowed of antioxidant and neuroprotective properties and plays a pivotal role in brain energy homeostasis. The purpose of this study was to
Mauricio Peña Cunha +8 more
doaj +1 more source
Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy
Advanced Science, EarlyView.This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang +5 more
wiley +1 more source
Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase
Neurobiology of Disease, 2004 There is substantial evidence that creatine administration exerts neuroprotective effects both in vitro and in vivo. The precise mechanisms for these neuroprotective effects however are as yet unclear.
Peter Klivenyi +7 more
doaj +1 more source