Results 91 to 100 of about 1,006,914 (379)

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Determination of creatinine level in patient blood samples by Fourier NIR spectroscopy and multivariate analysis in comparison with biochemical assay [PDF]

Journal of Innovative Optical Health Sciences, 2019
In this paper, in vivo spectra from 23 patients’ blood samples with various Creatinine (Cr) concentration levels ranging from 0.96 to 12.5 mg/dL were measured using Fourier transform near-infrared spectrometer (FT-NIRS) and spectrum quantitative analysis
Zvi Hai Barnea, David Abookasis
doaj   +1 more source

Acute kidney disease and renal recovery : consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup [PDF]

, 2017
Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice.
A Dewitte, A Ishani, A Ishani, A Morden, AB Pai, AG Schneider, AJ Lewington, Alexander Zarbock, AM Patel, AS Levey, Azra Bihorac, B Rodriguez-Iturbe, B Rodriguez-Iturbe, BB Newsome, BJ Philips, BS Moffett, C Mudumbai, C Ronco, C Vinsonneau, C-T Chao, CC Shiao, CJ Kirwan, Claudio Ronco, CM Bell, CM Horkan, CY Hsu, CY Hsu, D Korenkevych, D Ponce, D Schnell, David Bittleman, Dinna Cruz, DM Thomas, DW Brown, E Wang, EA Coleman, EA Hoste, EA Hoste, EA Hoste, ED Siew, ED Siew, ED Siew, ED Siew, ED Siew, Edward D. Siew, Eric Hoste, ES Kirkendall, Etienne Macedo, F Lapi, FG Brivet, GV do Nascimento, H de Geus, H Graf, H Schiffl, HL Smets, I Benz-de Bretagne, I Koulouridis, I Nachtigall, ID Bucaloiu, IH Khan, J Bouchard, J Bouchard, J Herrera, J Herrera, J Kaufman, J Zavada, JA Kellum, JA Kellum, JA Kellum, JA Kellum, Jay Koyner, JF Platt, JJ Dixon, JO Friedrich, John A. Kellum, JP Bosch, JP Nicholson, JR Brown, JR Brown, JR Prowle, JW Pickering, JW Pickering, K Doi, K Solez, Kathleen D. Liu, KD Liu, KR Pechman, L Cox, LA Tomlinson, Lakhmir S. Chawla, LJ Hickson, LS Chawla, LS Chawla, LS Chawla, LS Chawla, LS Chawla, Lui Forni, M Carlier, M Darmon, M Heung, M Heung, M Huber, M James, M Jun, M Monseu, M Xie, MA Onuigbo, Marlies Ostermann, MB Kwong, ME Matheny, Mitchell Rosner, Mitra Nadim, MM Chrymko, MM Sood, MT James, MT James, N Pannu, N Srisawat, Neesh Pannu, P Sharma, PA Duran, Patrick Murray, Paul M. Palevsky, PH van der Voort, PK Tao Li, PM Palevsky, PM Palevsky, R Cartin-Ceba, R Chu, R Jelliffe, R Rivosecchi, R Wald, R Wald, RA Parker, Ravindra Mehta, Rinaldo Bellomo, RK Basu, RL Amdur, RL Mehta, Robert L. Fitzgerald, Ron Wald, S Chen, S Ftouh, S Ninet, S Perinel, S Uchino, S Uchino, SA Silver, Sandra L. Kane-Gill, SC Gautam, Sean M. Bagshaw, SG Coca, SG Coca, SL Goldstein, SL Goldstein, SL Hu, SL Kane-Gill, SM Bagshaw, SM Handler, SM Jang, SM Lee, SM Moran, SP Kelleher, Stuart L. Goldstein, TJ Pianta, TY Wu, VC Wu, VC Wu, W Picard, Z Harel, ZH Endre, ZH Endre, ZL Cox, Zoltan Endre   +173 more
core   +2 more sources

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Serum creatinine: advantages and pitfalls

Journal of Laboratory and Precision Medicine, 2018
Serum creatinine (sCr) is today the most commonly used marker to estimate glomerular filtration rate (GFR). However, measuring and interpreting creatinine is not so simple.
A. Bargnoux, Nils Kuster, E. Cavalier, L. Pieroni, J. Souweine, P. Delanaye, J. Cristol   +6 more
semanticscholar   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Development of a Population Pharmacokinetic Gabapentin Model Leveraging Therapeutic Drug Monitoring Concentrations

Pharmaceutics
Background/Objectives: Gabapentin has variable pharmacokinetics (PK), which contributes to difficulty in dosing and increased risk of adverse events. The objective of this study was to leverage gabapentin concentrations from therapeutic drug monitoring ...
Firas Al-Zubaydi, Andrew Wassef, Leonid Kagan, Luigi Brunetti   +3 more
doaj   +1 more source

Unexpected Creatinine Values [PDF]

Clinical Chemistry, 2016
An 88-year-old man was admitted for acute coronary syndrome associated with renal dysfunction. Ten hours after admission, the patient was found to be hypotensive and treated with intravenous dobutamine injected via a central line. Enzymatically measured creatinine concentration (Roche Diagnostics, COBAS 8000) was significantly decreased 24 h after ...
Jean-Baptiste, Oudart, Imad Dali, Braham, François-Xavier, Maquart   +2 more
openaire   +2 more sources

C-Reactive protein and risk of ESRD: results from the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT) [PDF]

, 2016
Background: To better understand a potential association of elevated C-reactive protein (CRP) level with progression of chronic kidney disease (CKD), we examined the relationship of CRP level with the development of end-stage renal disease (ESRD) in ...
Burdmann, Emmanuel A., Claggett, Brian, Eckardt, Kai-Uwe, Kewalramani, Reshma, Levey, Andrew S., Mc Causland, Finnian R., McMurray, John J.V., Parfrey, Patrick, Pfeffer, Marc A., Remuzzi, Giuseppe, Singh, Ajay K., Solomon, Scott D., Toto, Robert D.   +12 more
core   +1 more source

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source