Results 161 to 170 of about 867,384 (315)

Predicting Heart Failure with Attention Learning Techniques Utilizing Cardiovascular Data [PDF]

arXiv
Cardiovascular diseases (CVDs) encompass a group of disorders affecting the heart and blood vessels, including conditions such as coronary artery disease, heart failure, stroke, and hypertension. In cardiovascular diseases, heart failure is one of the main causes of death and also long-term suffering in patients worldwide. Prediction is one of the risk
arxiv  

Mitigating Doxorubicin‐Induced Cardiotoxicity and Enhancing Anti‐Tumor Efficacy with a Metformin‐Integrated Self‐Assembled Nanomedicine

Advanced Science, EarlyView.
A novel self‐assembled nanomedicine (PMDDH) has been developed for the co‐delivery of doxorubicin and metformin, aiming to enhance the anti‐tumor efficacy of doxorubicin while alleviating its cardiotoxicity through the activation of cGAS‐STING and AMPK signaling pathways, respectively.
Jiaxin Huang, Jieru Yang, Yuanying Yang, Xiaofeng Lu, Juan Xu, Shan Lu, Hong Pan, Wenhu Zhou, Wenqun Li, Songwen Chen   +9 more
wiley   +1 more source

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

The effect of co-infection with hepatitis B and hepatitis C viruses on the prevalence of proteinuria and loss of renal function: a single-center experience

The Egyptian Journal of Internal Medicine, 2018
Introduction and aim of the work Patients infected with hepatitis B virus (HBV) or hepatitis C virus (HCV) are at increased risk of renal disease. This study compares factors associated with proteinuria and doubling of serum creatinine level in patients ...
Amin R Soliman, Rabab M Ahmed, Mahmoud Soliman, Ahmed Abdallah, Bahaa Zayed   +4 more
doaj   +1 more source

Reprogramming the Tumor Immune Microenvironment with ICAM‐1‐Targeted Antibody‒Drug Conjugates and B7‐H3‐CD3 Bispecific Antibodies

Advanced Science, EarlyView.
Reprogramming the tumor immune microenvironment is crucial for transforming immune “cold” tumors into “hot” inflammatory tumors. The investigation reveals that the combination of ICAM‐1‐Dxd with B7‐H3‐CD3 bispecific antibodies not only demonstrates significant inhibitory effects on tumor growth and metastasis but also plays a vital role in ...
Shoubing Zhou, Mengyu Hong, Dan Zhao, Wenyu Li, Xiaolong Yuan, Yinghong Wang, Hualong Li, Yang Yang, Tengchuan Jin, Jing Pan   +9 more
wiley   +1 more source

Cholecalciferol improves glycemic control in type 2 diabetic patients: a 6-month prospective interventional study

Therapeutics and Clinical Risk Management, 2017
Aml Mohamed Nada,1 Dalia Shaheen2 1Faculty of Medicine, Department of Internal Medicine, 2Faculty of Medicine, Department of Medical Biochemistry, Mansoura University, Mansoura, Egypt Background and purpose: To investigate the effects of vitamin D ...
Nada AM, Shaheen DA
doaj  

A Dual‐Response DNA Origami Platform for Imaging and Treatment of Sepsis‐Associated Acute Kidney Injury

Advanced Science, EarlyView.
A dual‐response DNA origami platform is developed for the early diagnosis and therapeutic intervention of sepsis‐associated acute kidney injury. Abstract Current diagnostics for sepsis‐associated acute kidney injury (SA‐AKI) detect kidney damage only at advanced stages, limiting opportunities for timely intervention. A DNA origami‐based nanoplatform is
Yingying Zhao, Yadan Zhao, Yufan Ling, Zhiming Chen, Xiaofeng Wu, Xing Lu, Yao He, Houyu Wang, Fenglin Dong   +8 more
wiley   +1 more source

Urbanization and non-communicable disease mortality in Thailand: an ecological correlation study.

, 2013
This study provides strong evidence from an LMIC that urbanization is associated with mortality from three lifestyle-associated diseases at an ecological level.
Allender, Allender, Archavanitkul, Banwell, Bentham, Boutayeb, Cochrane, Cohen, Faramnuayphol, Flood, Harpham, Hernandez, Holt-Lunstad, Kosulwat, Leon, Lim, Maheswaran, Mathers, Odton, Pattaraarchachai, Petcharoen, Phillips, Porapakkham, Pritchard, Rao, Schorr, Sethapongkul, Sleigh, Smith, Srimahachota, Tangcharoensatien, Vapattanawong, Venketasubramanian, Viravaidya, Vlahov, World Health Organization, Yang, Yiengprungsawan, Yiengprungsawan, Young   +39 more
core   +1 more source

Correlation between biomarkers of exposure, effect and potential harm in the urine of electronic cigarette users. [PDF]

, 2020
ObjectivesTo determine if urinary biomarkers of effect and potential harm are elevated in electronic cigarette users compared with non-smokers and if elevation correlates with increased concentrations of metals in urine.Study design and settingThis was a
Bates, Steve M, Goniewicz, Maciej Lukasz, Hua, My, Li, Jun, Lyons, Timothy W, Robinson, Andrew N, Sakamaki-Ching, Shane, Talbot, Prue, Williams, Monique   +8 more
core  

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Advanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu, Shaokang Pan, Hui Wang, Yong Liu, Yingjin Qiao, Zhangsuo Liu, Qi Feng   +9 more
wiley   +1 more source