Results 161 to 170 of about 935,466 (405)

Towards automated identification of changes in laboratory measurement of renal function: implications for longitudinal research and observing trends in glomerular filtration rate (GFR) [PDF]

arXiv, 2014
Introduction: Kidney function is reported using estimates of glomerular filtration rate (eGFR). However, eGFR values are recorded without reference to the creatinine (SCr) assays used to derive them, and newer assays were introduced at different time points across laboratories in UK. These changes may cause systematic bias in eGFR reported in routinely
arxiv  

Communications Among Neurocytes in Parkinson's Disease Regulated by Differential Metabolism and Blood‐Brain Barrier Traversing of Chiral Gold Cluster‐MOF Integrated Nanoparticles

Advanced Science, EarlyView.
This study have loaded chiral gold nanoclusters onto the inner and outer surfaces of ZIF and uncovers the biodistribution, metabolic variances, and therapeutic mechanism of chiral nanoparticles, providing deep insights into the nanobiological effects of chiral anti‐inflammatory nanomedicines in PD therapy for future clinical transformation.
Junyang Chen, Gaoxiang Xu, Runpu Shen, Jianzhong Xu, Congcong Lu, Xin Li, Qi Feng, Qing Li   +7 more
wiley   +1 more source

Urbanization and non-communicable disease mortality in Thailand: an ecological correlation study.

, 2013
This study provides strong evidence from an LMIC that urbanization is associated with mortality from three lifestyle-associated diseases at an ecological level.
Allender, Allender, Archavanitkul, Banwell, Bentham, Boutayeb, Cochrane, Cohen, Faramnuayphol, Flood, Harpham, Hernandez, Holt-Lunstad, Kosulwat, Leon, Lim, Maheswaran, Mathers, Odton, Pattaraarchachai, Petcharoen, Phillips, Porapakkham, Pritchard, Rao, Schorr, Sethapongkul, Sleigh, Smith, Srimahachota, Tangcharoensatien, Vapattanawong, Venketasubramanian, Viravaidya, Vlahov, World Health Organization, Yang, Yiengprungsawan, Yiengprungsawan, Young   +39 more
core   +1 more source

Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research [PDF]

, 2017
Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation.
Croubels, Siska, Delanghe, Joris, Devreese, Mathias, Gasthuys, Elke, Heyndrickx, Marjolein, Millecam, Joske, Sys, Stanislas, Vande Walle, Johan, Vanderperren, Katrien   +8 more
core   +3 more sources

Genetically Engineered IL12/CSF1R‐Macrophage Membrane‐Liposome Hybrid Nanovesicles for NIR‐II Fluorescence Imaging‐Guided and Membrane‐Targeted Mild Photothermal‐Immunotherapy of Glioblastoma

Advanced Science, EarlyView.
A theranostic nanoplatform is formulated with NIR‐II emissive lipophilic cyanine dye IRC18 to intercalate into genetically engineered IL12/CSF1R‐macrophage membrane‐liposome hybrid nanovesicles, which assists to achieve blood–brain barrier crossing, glioblastoma targeting, NIR‐II fluorescence imaging, image‐guided membrane‐targeted mild photothermal ...
Pengfei Chen, Yue Liu, Haiyan Huang, Menglong Li, Hui Xie, Shubham Roy, Jingsi Gu, Jian Jin, Kai Deng, Lixin Du, Bing Guo   +10 more
wiley   +1 more source

A Note on the Effect of Purgation on the Creatinine Content of Urine [PDF]

, 1920
David P. Burns
openalex   +1 more source

Estimating GFR using the CKD Epidemiology Collaboration (CKD-EPI) creatinine equation: more accurate GFR estimates, lower CKD prevalence estimates, and better risk predictions.

American Journal of Kidney Diseases, 2010
Serum creatinine is ordered more than 281 million times annually in the United States (based on the 191,354,358 creatinine tests reported in 1996 and assuming annual growth rate in testing of 3%),1 and recent reports show that more than 70% of ...
A. Levey, L. Stevens
semanticscholar   +1 more source

Clinical review: Biomarkers of acute kidney injury: where are we now? [PDF]

, 2012
The recognition that acute kidney injury (AKI) is a significant independent risk factor for morbidity and mortality has resulted in a substantial number of publications over the past 5 years or more.
Forni, LG, Ostermann, M, Philips, BJ
core   +1 more source

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

Predicting Heart Failure with Attention Learning Techniques Utilizing Cardiovascular Data [PDF]

arXiv
Cardiovascular diseases (CVDs) encompass a group of disorders affecting the heart and blood vessels, including conditions such as coronary artery disease, heart failure, stroke, and hypertension. In cardiovascular diseases, heart failure is one of the main causes of death and also long-term suffering in patients worldwide. Prediction is one of the risk
arxiv