Results 301 to 310 of about 935,466 (405)

Solanidine‐derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Phenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid (SSDA) and 4‐OH‐solanidine as diet‐derived cytochrome P450 2D6 (CYP2D6) biomarkers in a ...
Jens Andreas Sarömba, Julian Peter Müller, Jolanta Tupiec, Anjali Roeth, Berkan Kurt, Florian Kahles, Thea Laurentius, Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) in Children with Congenital Heart Diseases in Southwest Nigeria. [PDF]

Ann Card Anaesth
Makinde RA, Alaje AK, Ajose AO, Adedeji TA, Onakpoya UU.   +4 more
europepmc   +1 more source

Effect of hydration schedules on dose‐limiting toxicity in patients with head and neck squamous cell carcinoma treated with cisplatin

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to determine if head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin chemoradiotherapy and short hydration (SH) experience less dose‐limiting toxicity (DLT) and receive more cisplatin than those with medium hydration (MH) or long hydration (LH).
Anouk W. M. A. Schaeffers, Cassimy B. van Neerven, Dorieke van Balen, Mirjam Crul, Marije Slingerland, Saskia A. C. Luelmo, Jan Paul de Boer, Jens Voortman, Arjan D. van Zuilen, Remco de Bree, Lot A. Devriese   +10 more
wiley   +1 more source

Feasibility of replacing ^99mTc-DTPA GFR measurements with eGFR from cystatin C in individuals with spinal cord injuries. [PDF]

Physiol Rep
Kristensen T, Oturai PS, Haddock BT, Biering-Sørensen F, Kruuse C, Andersen UB.   +5 more
europepmc   +1 more source

A HITHERTO NEGLECTED FACTOR AFFECTING THE DETERMINATION OF MINUTE QUANTITIES OF CREATININE

, 1916
Andrew Hunter, Walter R. Campbell
openalex   +1 more source

The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this phase 1 trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone (previously AZD9977) in participants with severe renal impairment vs. those with normal renal function. Methods Participants with severe renal impairment (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2) not on dialysis were ...
Chandrali S. Bhattacharya, Hans Ericsson, Susanne Johansson, Joanna Parkinson, Simina M. Boca, Ye Yang, Maria Heijer, Greggory Housler, Maria Leonsson‐Zachrisson, Judith Hartleib‐Geschwindner, Patricia Ely Pizzato   +10 more
wiley   +1 more source

Tubulointerstitial nephritis and uveitis post COVID-19 infection in an adult. [PDF]

BMJ Case Rep
Lau J, Tan KS.
europepmc   +1 more source

Assessment of ethnic differences in pharmacokinetics and clinical responses of acalabrutinib between Chinese and White patients with B‐cell malignancies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to assess differences between Chinese and White patients in pharmacokinetics (PK) of, and clinical response to, acalabrutinib and its pharmacologically active major metabolite, ACP‐5862, to support recommended dosing in Chinese patients with B‐cell malignancies.
Tingting Yao, Junjie Ding, Shringi Sharma, Yunfei Li, Qianwei Xu, Peiming Ma   +5 more
wiley   +1 more source

Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients. [PDF]

Sci Rep
Smekal AK, Swartling M, Nielsen EI, Furebring M, Larsson AO, Lipcsey M.   +5 more
europepmc   +1 more source

Choice of Reference Serum Creatinine in Defining Acute Kidney Injury

Nephron, 2015
E. Siew, M. Matheny
semanticscholar   +1 more source