Animal Models and Experimental Medicine, EarlyView.An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen +12 more
wiley +1 more source
Biomarkers influence kidney function estimates more so than race among persons with HIV. [PDF]
AIDS Res TherObeng-Nyarkoh PA +8 more
europepmc +1 more source
Establishment of a novel cynomolgus monkey model of hyperuricemia
Animal Models and Experimental Medicine, EarlyView.We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang +12 more
wiley +1 more source
Abnormal Serum Albumin, Alanine Aminotransferase, and Blood Urea Nitrogen are Associated with Higher Risks for Mechanical Ventilation and In-Hospital Mortality in COVID-19 Positive US Veterans. [PDF]
Biomark InsightsMoss WD +8 more
europepmc +1 more source
Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas
Annals of Neurology, EarlyView.Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek +7 more
wiley +1 more source
Creatinine Decline Rate as a Predictor of Renal Recovery After Acute Kidney Injury: A Retrospective Cohort Study. [PDF]
Diagnostics (Basel)Öneç K, Altun G, Sav T.
europepmc +1 more source
Annals of Neurology, EarlyView.Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios +5 more
wiley +1 more source
Thiophene structure influences plasmonic creatinine sensing through molecular interaction and surface morphology. [PDF]
Sci RepZakaria NI +9 more
europepmc +1 more source
The Epidemiology of Primary Lateral Sclerosis: Results from a Population‐Based Cohort
Annals of Neurology, EarlyView.Objective In this population‐based study, we described the epidemiology of primary lateral sclerosis (PLS) in northern Italy and compared the clinical characteristics of patients with PLS to those with predominant upper motor neuron (PUMN) involvement and classic amyotrophic lateral sclerosis (ALS).
Rosario Vasta +17 more
wiley +1 more source
Renal safety of intraoperative local vancomycin powder application in orthopedic surgery: a retrospective analysis. [PDF]
J Bone Jt InfectBeschauner J +5 more
europepmc +1 more source