Results 71 to 80 of about 387,760 (267)

Integrated Genomic Analysis Reveals the Impact of Avermectin on Chromatin Structure and Gene Expression Regulation in Bombyx mori

Insects
Avermectin is a widely used insecticide for pest control, such as the Plutella xylostella. Despite its efficacy in pest management, concerns have been raised regarding its effect on non-target species, such as the important economic insect silkworm ...
Yongkang Guo, Tong Zhang, Wei Lu, Dan Liu, Junjie Lao, Na Zhang, Hao Sun, Ling Jia, Sanyuan Ma   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pu-erh tea attenuates obesity by remodeling gut microbiota and activating energy expenditure

Frontiers in Microbiology
IntroductionEnergy excess-induced obesity has emerged as a global public health concern, and Pu-erh tea has attracted extensive research interest due to its prominent anti-obesity potential. This study aimed to investigate the anti-obesity activity of Pu-
Xiujuan Jiang, Fan Wu, Mianhong Xu, Liyong Luo, Liang Zeng   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Integrated Physiological, Transcriptomic, and Metabolomic Analysis Reveals Mechanism Underlying the Serendipita indica-Enhanced Drought Tolerance in Tea Plants

Plants
Drought stress significantly impairs the output of tea plants and the quality of tea products. Although Serendipita indica has demonstrated the ability to enhance drought tolerance in host plants, its impact on tea plants (Camellia sinensis) experiencing
Gaojian Shen, Hongli Cao, Qin Zeng, Xiaoyu Guo, Huixin Shao, Huiyi Wang, Liyong Luo, Chuan Yue, Liang Zeng   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Genome-Wide Identification and Expression Analysis of Aquaporin Gene Family in Tea Plant (Camellia sinensis)

Plants
Aquaporins (AQPs) facilitate transmembrane transport of water and small solutes, critically influencing plant growth, development, and stress adaptation. However, tea plant AQPs (CsAQPs) remain incompletely characterized genome-wide.
Huiyi Wang, Jiaojiao Tuo, Huixin Shao, Shiyi Chen, Hongli Cao, Chuan Yue   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

New Insight on the Sublethal Effect of Bt-Cry1Ab in Spodoptera litura (Fabricius): Tissular Distribution of Cry1Ab, Ultrastructural Alterations and the Lysosomal Response

Insects
Bt has been applied as a gene source for insect-resistant transgenic crops, which represents efficient control of insect pests. In this study, we evaluated the pesticidal specificity of one Bt maize strain, DBN9936, that expresses Cry1Ab protein in ...
Yan-Jue Wang, Ya-Qin Shen, Ying-Dan Xiao, Xue Yang, Shao-Peng Hao, Jian-Qiu Liu, Xiao-Xue Yang, Kazuei Mita, Ya-Jing Xu   +8 more
doaj   +1 more source