Results 31 to 40 of about 727 (265)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Comparing Contemporary Evangelical Models Regarding Human Origins
Religions, 2023 Multiple viewpoints exist among Protestant Evangelical Christians regarding human origins, with each offering different answers to questions regarding the existence of Adam and Eve and their relationship to humanity, common human–ape ancestry, evolution ...
Casey Luskin
doaj +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Creation and evolution: A relationship fraught with misunderstandings
HTS Teologiese Studies/Theological Studies, 2019 The relationship between evolution and creation, both religiously and ideologically, continues to be a source of misunderstandings that occur at various levels and is further explored in this article.
Martin Rothgangel
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Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Cultural-Symbolic World Picture of the Latin Christian Middle Ages: The Ontological Dimension
Наукові записки НаУКМА: Філософія та релігієзнавство, 2020 The present paper is a continuation of the previous appearances by the author addressing the phenomenon of the cultural-symbolic world pictures as typologically founded in the “epoch-making” ontologies and culturally expressed versions of history.
Yurii Svatko
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A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Cosmology and Politics in Ancient Greek Thought [PDF]
Философия и космология, 2018 The political dimension of Plato’s cosmological thought has been extensively explored as such and in its relation with Greek culture, but there remains a question of methodology. Which context will be more appropriate for Plato’s works? Shall we focus on
Eugene Afonasin
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FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source