Results 41 to 50 of about 2,578 (310)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The Scientific Creationism [PDF]
Annals of Philosophy, Social and Human Disciplines, 2016 The subject of the present paper is the analysis of the origin of the universe, time, life, mankind and of the geological column, from the perspective of the creationist model, and through comparisons with the evolutionist model.
Raluca Marinela SILAGHI
doaj
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Comparing Contemporary Evangelical Models Regarding Human Origins
Religions, 2023 Multiple viewpoints exist among Protestant Evangelical Christians regarding human origins, with each offering different answers to questions regarding the existence of Adam and Eve and their relationship to humanity, common human–ape ancestry, evolution ...
Casey Luskin
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Nature Structural Biology, 2002 Cells produce proteases as inactive zymogens. Here, we demonstrate that this tactic can extend beyond proteases. By linking the N and C termini of ribonuclease A, we obstruct the active site with the amino acid sequence recognized by plasmepsin II, a highly specific protease from Plasmodium falciparum.
Parit, Plainkum +3 more
openaire +2 more sources
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Creation and evolution: A relationship fraught with misunderstandings
HTS Teologiese Studies/Theological Studies, 2019 The relationship between evolution and creation, both religiously and ideologically, continues to be a source of misunderstandings that occur at various levels and is further explored in this article.
Martin Rothgangel
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FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Intelligent Design and Resurgent Creationism
, 2017 This chapter examines the antievolutionists' move away from arguing with scientists and toward providing a scientific-sounding argument for mass consumption, usually in the guise of “intelligent design” (ID)—a tactic that allowed creationism to appeal to
Edward Caudill
core +1 more source