Results 51 to 60 of about 73,896 (248)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Variation in Specificity of HIV Rapid Diagnostic Tests over Place and Time: An Analysis of Discordancy Data Using a Bayesian Approach [PDF]

, 2015
BACKGROUND Recent trends to earlier access to anti-retroviral treatment underline the importance of accurate HIV diagnosis. The WHO HIV testing strategy recommends the use of two or three rapid diagnostic tests (RDTs) combined in an algorithm and assume ...
Glass, Kathryn, Klarkowski, Derryck, Lokuge, Kamalini, O’Brien, Daniel, Piriou, Erwan, Shanks, Leslie   +5 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Men procuring sexual services from women: everyman or peculiar man? [PDF]

, 2015
Objective: To explore characteristics of men procuring sexual services from women. Design: Quantitative study using questionnaires and purposive sampling.
Birch, Philip, Ireland, Jane Louise
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Managing Psychopathic Employees [PDF]

, 2010
[Excerpt] What if a small but definable subset of the employee population were responsible for a major share of corporate crime and ethical breaches? If so, then developing policies that target them would improve the firm’s performance, not to mention ...
Langbert, Mitchell B.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Crisis, Identity, and Intoxication: Youth Drug Abuse and Socio-Economic Marginalization in Post-2000s Zimbabwe

Baileo
Drug and substance abuse among Zimbabwean youth in the post-2000 era has reached an alarming crisis level. This study aims to examine emerging trends in substance abuse practices among young people and to evaluate the effectiveness of existing ...
Ruvimbo Nyatsanza, Farai Tendai Nyoni, Takudzwa Chiremba   +2 more
doaj   +1 more source

Understanding local ethnic inequalities in childhood BMI through cross-sectional analysis of routinely collected local data [PDF]

, 2019
Background: Local-level analysis of ethnic inequalities in health is lacking, prohibiting a comprehensive understanding of the health needs of local populations and the design of effective health services.
A Mu'Min Chowdhury, A Must, A Zilanawala, AM El-Sayed, B Butland, Catherine L Falconer, CL Falconer, D Haroun, Department of Health, DS Freedman, F Sallis, G Leckie, G Leung, H Dinsdale, J Liu, J Rasbash, J Trigwell, J van Hook, J Williams, K Harrison, KK Davison, M Delavari, M Murphy, Marie Murphy, Marsha Towey, MJ Pallan, MJ Tovée, MT Hudda, N Townsend, N Townsend, Nicholas R. Parsons, NJ Shaw, Public Health England, RE Johnson, Rebecca Johnson, S Brophy, S Karlsen, S Kumanyika, S Toselli, SR Daniels, TJ Cole, TJ Cole, TJ Cole, Wendy Robertson, Y Wang   +44 more
core   +2 more sources