Results 81 to 90 of about 73,896 (248)

How can leaders trigger bottom-up innovation? [PDF]

The current study explores what particular leader behaviour enhances the innovative behaviour of employees. Last year we made an extensive literature review.
Jeroen de Jong
core  

Environmental and Human Controls of Ecosystem Functional Diversity in Temperate South America [PDF]

, 2013
The regional controls of biodiversity patterns have been traditionally evaluated using structural and compositional components at the species level, but evaluation of the functional component at the ecosystem level is still scarce.
Alcaraz Segura, Domingo, Cabello Piñar, Francisco Javier, Epstein, Howard, Paruelo Suarez, José María   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

CREATIVE DEVIANTOLOGY: EXPERIENCE OF AMPLIFICATION

Вестник Кемеровского государственного университета, 2015
The paper presents the first Russian experience of institutionalizing Creative Deviantology as a special scientific and academic discipline. The author emphasizes Creative Deviantology’s acquisition of its scientific syntagma which contributes to ...
Yu. A. Klayberg
doaj  

An examination of factors influencing the choice of therapy for patients with coronary artery disease [PDF]

, 2006
Background A diverse range of factors influence clinicians' decisions regarding the allocation of patients to different treatments for coronary artery disease in routine cardiology clinics. These include demographic measures, risk factors, co-morbidities,
Hirani, S, Hyam, JA, Newman, SP, Shaefi, S, Walesby, RK, Walker, JM   +5 more
core  

Research Review On The Formation Mechanism of Architectural Designers’ Creative Deviance

International Journal of Sociologies and Anthropologies Science Reviews
Background and Aims: In the realm of construction project management and standardized design processes, enterprises encounter challenges in fostering innovation. Of particular interest is transgressive innovation behavior, a less understood form of autonomous innovation that has drawn scholarly attention. Innovators employ various strategies to advance
Dekun Zhu, Ren Xu
openaire   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Experiences of Emotion Management in Medical Care (Case Study: Toronto)

جامعه شناسی کاربردی, 2013
Introduction   This study lies at the intersection of the sociology of emotions and medical sociology, investigating emotion management among a rather unknown category of medical personnel –Hospital Chaplains.
Masoud Kianpour
doaj