Results 31 to 40 of about 4,077 (254)

Entre diabolisation, séduction et légitimation. Le kitsch ou l’imitation comme « mal esthétique » ?

open access: yesCahiers d’Études Germaniques, 2017
On the basis of Clement Greenberg’s distinction between the avant-garde as “imitating the act of imitation” and kitsch as “imitating the effect of imitation” in order to provoke the pleasure of the senses, we will show that kitsch induces a “culinary ...
Florence BANCAUD
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Notes sur la part d’imitation dans l’innovation en architecture

open access: yesLes Cahiers de la Recherche Architecturale, Urbaine et Paysagère, 2018
Does an architect become innovative when they exhibit esthetically creative work, when they use new materials or when they engage unusual methods ?
Rémi Laporte
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Imitation as Factor of Developing Higher Abilities in Children: Resource Approach

open access: yesRUDN Journal of Psychology and Pedagogics, 2014
The phenomenon of “imitation” in children is analyzed. The possibility of the use of imitation for development of higher abilities (mostly creative) in children is studied.
G V Ozhiganova
doaj  

The Alphabet of Architecture. Originality and Literacy in the Theory of Profiles

open access: yesRA. Revista de Arquitectura, 2022
In 1691 Augustin-Charles D’Aviler published his Cours d’architecture qui comprend les ordres de Vignole. Ostensibly one of the many extended editions of Vignola’s Regola delli cinque ordini d’architettura (1562) that would appear over the course of the ...
Maarten Delbeke
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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