Results 31 to 40 of about 3,358 (255)
Notes sur la part d’imitation dans l’innovation en architecture
Les Cahiers de la Recherche Architecturale, Urbaine et Paysagère, 2018 Does an architect become innovative when they exhibit esthetically creative work, when they use new materials or when they engage unusual methods ?
Rémi Laporte
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Alphabet of Architecture. Originality and Literacy in the Theory of Profiles
RA. Revista de Arquitectura, 2022 In 1691 Augustin-Charles D’Aviler published his Cours d’architecture qui comprend les ordres de Vignole. Ostensibly one of the many extended editions of Vignola’s Regola delli cinque ordini d’architettura (1562) that would appear over the course of the ...
Maarten Delbeke
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Imitation as Factor of Developing Higher Abilities in Children: Resource Approach
RUDN Journal of Psychology and Pedagogics, 2014 The phenomenon of “imitation” in children is analyzed. The possibility of the use of imitation for development of higher abilities (mostly creative) in children is studied.
G V Ozhiganova
doaj
Les traductions moldaves au début du xixe siècle entre mode et nécessité
Recherches, 2013 With the start of the 19th-century, in a Moldavian literature at the dawn of Romanticism, the French pattern generated the development of some inspiring guidelines for the modern Romanian literature by translation, imitation and adaptation.
Mihaela Doboș
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source