Results 41 to 50 of about 19,901 (261)

The Role of Local and Regional Factors in the Development of Creative Clusters

Studia i Materiały, 2017
Creative industries tend to concentrate around large and medium cities forming creative local production systems. The article will present literature review focused on the role of creative cities in such aspects as: knowledge centers, entrepreneurship ...
Anna Szopa
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A Behavioral Approach Design for Supporting Sitting Facilities at The Lounge Area Of Minangkabau International Airport (BIM)

Mudra: Jurnal Seni Budaya
Minangkabau International Airport (BIM) located in West Sumatera is used as the main air transportation mode to travel outside the province. When waiting for flights, passengers will be in the airport lounge.
Faiz Alghifary, Imtihan Hanom
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

“Communal News Work” as Sustainable Business Model: Recent Print-Centric News Start-Ups in Regional Queensland

Media and Communication
The Covid-19 emergency in Australia precipitated the closure of dozens of print newspapers across Australia but, conversely, the heightened state of anxiety of the early Covid-19 period amplified the need for local information and communality.
Harry Dugmore, Renee Barnes, Peter English, Elizabeth J. Stephens, Rosanna Natoli   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Artificial intelligence in project management: A bibliometric analysis [PDF]

Problems and Perspectives in Management
This study explores the integration of artificial intelligence (AI) into project management through a bibliometric analysis of scholarly publications and patents from 2001 to 2024.
Nurkhat Ibadildin, Zhaxat Kenzhin, Gaukhar Yeshenkulova, Rymkul Ismailova, Assel Nurguzhina, Samalgul Nassanbekova, Aiman Kadyrova   +6 more
doaj   +1 more source

Urban Connective Action: The Case of Events Hosted in Public Space

Urban Planning, 2020
In the past decade, significant transformations have influenced the governance of urban public spaces. There has also been a growth in new public spheres associated with digital media networks, informing and influencing the production and regulation of ...
David McGillivray, Severin Guillard, Emma Reid   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source