Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
RELATIONSHIP BETWEEN STUDENTS’ ABILITY TO ACHIEVE DESIGN TASKS AND CREATIVE THINKING SKILLS
Creative thinking provides students to solve complex problems, through searching for new learning ways in educational activities. This study aimed to reveal higher education students' creative thinking potentials with educational activities.
Kani ÜLGER
doaj
Artificially Enhanced Performing Arts. Experiment on the Creative use of AI in Performing Arts
This article explores the Artificially Enhanced Performing Arts workshop, which took place in Bologna from January 15 to 19, 2024, as part of a collaboration between the Department of Arts at the University of Bologna and the Seoul Institute of the Arts.
Andrea Paciotto
doaj +1 more source
The Category of Artistic Thinking and the Conception of Roman Ingarden’s Aesthetic Situation [PDF]
The aim of this paper is to examine the validity and utility of the category of artistic thinking through applying it to the description of an aesthetic situation as given by Roman Ingarden.
Paweł Chorzępa, Dominika Czakon
doaj
Evaluative Skill in the Creative Process: A Cross-cultural Study. [PDF]
Guo Y +4 more
europepmc +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Exploring the Creative Industries: Toward a Classification by Process and Job Functions
In Europe, the creative industries (CIs) are experiencing growth rates well above the average of the EU’s total economic growth. However, a lack of consensus regarding how these industries work impedes the development of effective policy. In our research,
Mirjam M. Koehorst +3 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Employees' Green Enterprise Motivation and Green Creative Process Engagement and Their Impact on Green Creative Performance. [PDF]
Hu X +5 more
europepmc +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source

