Results 41 to 50 of about 155,339 (259)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
TECHNOLOGY OF CREATIVE FORMATION STUDENTS 'PERSONALITIES IN EDUCATIONAL PROCESSES
The conditions of the educational process and the conditions of its organization form methods, which help to develop the Creative qualifies of a person a covered in the article.
N.I. Zelenkova
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
VALUING CREATIVE WRITING TECHNIQUES IN SPACE REPRESENTATION AND GEOGRAPHICAL PROCESSES [PDF]
In this paper, we present some creative writing activities in which three techniques have been used: the comics, the writing marathon, and the lost manuscript.
RALUCA-CLAUDIA CASSIANU
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Interdisciplinary arts-charged creative processes as vehicles for knowledge production
Is Research-Creation a valid and legitimate mode of knowledge production? This was a question posed as the theme of a panel discussion at the 2023 de la mise en culture de la science à la recherche-création that took place at the École des Arts ...
Jiayi Young
doaj +1 more source
Creativity is a notion awakening growing interest in the social sciences. This attention mirrors the debate on the potential economic and social development of creativity as a skill, profession or industry.
Juan Arturo Rubio-Arostegui +2 more
doaj +1 more source
Biophysical approaches for studying viral entry
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Critique de processus de création : une approche théorique possible
The object of this article is to present the research on creative processes developed at the Pontifical Catholic University of São Paulo/Brazil (PUC/SP) since 1990.
Cecilia Almeida Salles
doaj +1 more source

