Results 131 to 140 of about 1,391,241 (279)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Creative thinking in prospective teachers: the status quo and the impact of contextual factors

open access: yesSouth African Journal of Education, 2010
To create unique and appropriate learning opportunities and environments and to nurture the development of creative thinking abilities among learners are some of the demands for creative thinking currently expected of teachers globally and also in South ...
Hannetjie Meintjes, Mary Grosser
doaj  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

ANALISIS PROSES BERPIKIR KREATIF SISWA SEKOLAH MENENGAH KEJURURUAN (SMK) DALAM PEMECAHAN DAN PENGAJUAN MASALAH MATEMATIKA PADA MATERI PERSAMAAN KUADRAT [PDF]

open access: yes, 2013
This research was aimed at identifying and describing students creativity level, creative thinking process and the factors which cause the students became not creative in solving and posing mathematics problems.
Prianggono, Agus, Riyadi,, Triyanto,
core  

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Towards pedagogies of creative collaboration: guiding secondary school students' music compositions [PDF]

open access: yes, 2014
The pedagogy of creative collaboration in music classrooms is hardly clear from the literature. There are plenty of strategies for setting up composition activities and some useful models for peer and self-assessment.
Odena, Oscar
core  

TREX1, a predator for treating MSI‐H tumors?

open access: yesMolecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya   +2 more
wiley   +1 more source

Pengaruh Model Pembelajaran Berbasis Masalah terhadap Kemampuan Berpikir Kritis dan Kemampuan Berpikir Kreatif [PDF]

open access: yes, 2016
The purpose of the study was to determine the role of problem-based learning model to critical thinking ability and creative thinking ability. The subjects were students of semester IV Mathematics Education Study Program, University of Indraprasta PGRI ...
Pujiati, A. (Anik)   +1 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

SENIOR HIGH SCHOOL STUDENTS' THINKING AND SELF EFFICACY IN INQUIRY LEARNING [PDF]

open access: yes, 2010
The problem of this research is the weakness of mathematical creative thinking ability, and students’ self efficacy which is the product of teacher–centered learning process.
Risnanosanti, -
core  

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