Results 31 to 40 of about 435,061 (198)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Four PPPPerspectives on Computational Creativity [PDF]
, 2015 From what perspective should creativity of a system be considered? Are we interested in the creativity of the system’s out- put? The creativity of the system itself? Or of its creative processes? Creativity as measured by internal features or by external
Jordanous, Anna
core
Materials & Design, 2023 The microstructure of Ti-6.5Al-2Zr-1Mo-1 V (TA15) alloy fabricated by laser powder bed fusion (LPBF) is characterized by the ultrafine α′ martensite with a high density of dislocations and twins, which is distinct to that of conventionally forged TA15 ...
Yu Zhang +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Scientific ReportsPrevious studies suggest that taking breaks from creative problem solving (i.e., incubation periods) enhances subsequent performance, possibly due to mind wandering during these breaks. The present preregistered study investigated whether different types
Colin McDaniel +2 more
doaj +1 more source
EntropyThe Categorical Compositional Distributional (DisCoCat) model has been proven to be very successful in modelling sentence meaning as the interaction of word meanings. Words are modelled as quantum states, interacting guided by grammar.
Jurek Eisinger +3 more
doaj +1 more source
Frontiers in Psychology, 2013 How does witnessing a hateful person in pain compare to witnessing a likable person in pain? The current study compared the brain bases for how we perceive likable people in pain with those of viewing hateful people in pain.
Glenn Ryan Fox +9 more
doaj +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Creativity in the Advertisement Domain: The Role of Experience on Creative Achievement
Frontiers in Psychology, 2019 The creativity of an advertisement campaign is one of the most relevant predictors of its success. Past research has highlighted the relevance of domain-specific experience in enhancing creativity, but the results are controversial.
Sergio Agnoli +5 more
doaj +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source