Results 161 to 170 of about 91,942 (288)

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, Volume 65, Issue 10, Page 2038-2048, October 2026.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source

The TPx Protein of <i>Cysticercus cellulosae</i> Promotes an IL-10-Producing Regulatory B Cell Phenotype in Human B Lymphoblastoid Cells via the cAMP/CREB Pathway. [PDF]

Cells
Cai H, Li X, Xiong H, Mu Q, Zhou B.
europepmc   +1 more source

E3 Ubiquitin Ligases in MASH‐Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities

Liver International, Volume 46, Issue 10, October 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a major cause of progressive liver fibrosis and can ultimately lead to cirrhosis and hepatocellular carcinoma (HCC). MASH‐associated liver fibrosis develops through a complex interplay among lipotoxic hepatocyte injury, oxidative and endoplasmic reticulum stress, inflammatory ...
Ah‐Reum Oh, Yelin Jeong, Young Hoon Jung, Young Un Kim, HyunJoon Gi, Do‐Wan Kim, Young Du Choi, Sang Bae Lee, KyeongJin Kim   +8 more
wiley   +1 more source

Molecular mechanisms by which tumor cell CD73-mediated adenosine signaling drives M2 polarization of macrophages in non-small cell lung cancer. [PDF]

Front Cell Dev Biol
Zheng Q, Qin B, Shen B, Huang Y, Zhu J, Hu J, Zheng X, Cai J, Xie Y, Song Y.   +9 more
europepmc   +1 more source

Annexin A4 Deficient Ventricular Myocytes Display Advanced Hypertrophy and Electrical Remodeling With Chronic β‐Adrenoceptor Stimulation

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Annexin A4 (A4) inhibits adenylyl cyclase 5 and may protect the heart during chronic β‐adrenergic stress. After 7 days of isoprenaline, A4‐deficient mice showed greater cardiomyocyte hypertrophy, prolonged action potentials, reduced Ito, preserved ICaL with altered activation, increased NCX1, and enhanced acute cAMP responsiveness compared with wild ...
Florentina Pluteanu, Alexander Heinick, Manuel Domnik‐Lehnert, Frank U. Müller, Christina Hermes   +4 more
wiley   +1 more source

SGLT2 Inhibition Attenuates Hippocampal Injury and Cognitive Impairment in Adult-Onset Hypothyroidism. [PDF]

J Biochem Mol Toxicol
Bitiktaş S, Yiğit S, Yeşilyurt İ, Gul HF, Erkan O, Gulakar B, Aydın ZC, Kahraman AA.   +7 more
europepmc   +1 more source

Cognitive-Enhancing Effects of Hesperetin-Rich CNE against Neuronal Damage and Memory Impairment by Regulating AKT/Nrf2 and BDNF/CREB Signaling. [PDF]

Biomol Ther (Seoul)
Kim HJ, Kim YE, Yu JS, Lee G, Kim SS, Yang HO.   +5 more
europepmc   +1 more source

Structure‐Guided Optimization of PDE9A Inhibitors Tackling Neuroinflammation: A Combined Computational and In Vitro Study

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Computational studies allowed the identification of a PDE9A inhibitor. A novel HPLC‐based assay was developed and optimized to measure enzyme function to assess PDE9A inhibition. Furthermore, in vitro tests supported the activity of the compound against neuroinflammation. Oxidative stress and inflammation are key players in central nervous system (CNS)
Giovanni Ribaudo, Elisa Landucci, Margrate Anyanwu, Costanza Mazzantini, Matteo Giannangeli, Stefano Rosa, Francesca Mainolfi, Maura Calvani, Maurizio Memo, Domenico E. Pellegrini‐Giampietro, Alessandra Gianoncelli   +10 more
wiley   +1 more source

Cryptocurrencies, Blockchain and Regulation: A Review

Lahore Journal of Economics
The evolution of money has accompanied the development of civilizations and technological innovations, leading to today’s cryptocurrencies. Cryptocurrencies have become a popular mode of payment globally because of their low cost, high-speed ...
Ayesha Afzal, Aiman Asif
doaj  

PT320, a GLP-1 receptor agonist, mitigates nucleus accumbens-associated depression- and anxiety-like behaviors in MitoPark mice of Parkinson's disease. [PDF]

J Parkinsons Dis
Tseng KY, Kuo TT, Chang PK, Chou JL, Huang EY, Greig NH, Choi HI, Olson L, Hoffer BJ, Chen YH.   +9 more
europepmc   +1 more source