Results 161 to 170 of about 139,153 (288)

The endocrine product of renal (preglomerular) contractile pericytes depends on prolyl‐4‐hydroxylases 2 and 3

The Journal of Physiology, EarlyView.
Abstract figure legend Preglomerular pericyte‐like SMMHC+ vascular smooth muscle cells (VSMCs) display marked endocrine plasticity. Hypotension caused by salt depletion and angiotensin‐converting enzyme (ACE) inhibition induces a reversible transformation of these VSMCs toward an endocrine state that produces renin.
Bettina K. M. Firmke, Lena M. Süß, Anna‐Lena Forst, Armin Kurtz, Katharina A.‐E. Broeker   +4 more
wiley   +1 more source

Moxa-combustion byproducts improve cognitive function via olfactory-mediated modulation of the GSK-3β/CREB pathway. [PDF]

Front Neurosci
Wu JW, Liu YJ, He J, Shi YQ, Zhao BX.
europepmc   +1 more source

c‐Jun N‐terminal kinase 3 as a permissive regulator of β‐cell incretin responsiveness

Journal of Diabetes Investigation, EarlyView.
Yuji Yamazaki
wiley   +1 more source

Chronic attenuation of brain leptin signalling is associated with early metabolic dysfunction in lean rats

The Journal of Physiology, EarlyView.
Abstract figure legend Central leptin signalling blockade induces early metabolic dysfunction. Intracerebroventricular infusion of a leptin receptor antagonist (SLA) in rats disrupts hypothalamic leptin signalling, leading to reduced signal transducer and activator of transcription 3 (STAT3) activation, decreased Socs3 and Pomc expression, and ...
Cristina Pintado, Lorena Mazuecos, Óscar Gómez‐Torres, Beatriz Merino, Elena Casanueva‐Álvarez, Blanca Rubio, Emma Burgos‐Ramos, Sara Artigas‐Jerónimo, Eduardo Moltó, Inés María Ramos, Justa María Poveda, Germán Perdomo, Irene Cózar‐Castellano, Carmen Arribas, Ernesto Bernal‐Mizrachi, Antonio Andrés, Nilda Gallardo   +16 more
wiley   +1 more source

Histamine H₁ Receptor-Mediated CREB Phosphorylation via G_q Protein Signaling and Arrestin Modulation. [PDF]

Pharmaceuticals (Basel)
Ogami R, Michinaga S, Iiboshi Y, Ogawa Y, Hishinuma S.   +4 more
europepmc   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Fluoxetine Repurposing Mitigates Alzheimer's Disease Pathology via the GSK3β-CREB-ADAM10 Axis. [PDF]

Int J Mol Sci
Lee SH, Son Y, Jang H, Kim HY, Kim KS, Lee HS, Lee HJ.   +6 more
europepmc   +1 more source

Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (noncompetitive NMDA receptor inhibitor), memantine (low‐affinity extrasynaptic‐NMDA ...
Motohiro Okada, Ruri Okubo, Tomoka Oka, Eishi Motomura   +3 more
wiley   +1 more source

Transcriptomic analysis reveals the hepatic response mechanisms of the Chinese spiny frog (Quasipaa spinosa) to Citrobacter freundii infection

Journal of the World Aquaculture Society, Volume 57, Issue 3, June 2026.
Abstract To elucidate the pathogen and host response mechanisms underlying mass mortality in Quasipaa spinosa, dominant bacteria were isolated from diseased individuals and identified as Citrobacter freundii by morphological, physiological, and biochemical characterization, 16S rRNA sequencing, and phylogenetic analysis.
Yanhong Li, Baohong Zhou, Yiran Lu, Yi Zang, Minghao Hu, Qiaochen Jin, Wenbin Fang, Shanjian Zheng   +7 more
wiley   +1 more source