Results 181 to 190 of about 87,086 (298)

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source

Memory Impairments: Type, Causes, and Molecular Players-Memory Dysfunction Across Neurologic Insults. [PDF]

Cells
Farooqui SA, Santerre M, Shcherbik N, Sawaya BE.   +3 more
europepmc   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, Volume 46, Issue 4, Page 921-944, July 2026.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Phosphorylation deficient inducible cAMP early repressor (ICER) modulates tumorigenesis and survival in a transgenic zebrafish (Danio rerio) model of melanoma

Biology Open
Justin Wheelan, Melissa Spigelman, Angelo Cirinelli, James Reilly, Carlos A. Molina   +4 more
doaj   +1 more source

Effects of Electroacupuncture on Knee Osteoarthritis in Rats Through Suppressing p38 MAPK/ERK/CREB Pathway. [PDF]

J Inflamm Res
Wang J, Wang F, Guo Y, Liu T, Li J, Zou J, Luan F, Gao T, Wang W.   +8 more
europepmc   +1 more source

Sequence‐encoded differences in the conformational ensembles of CITED transcriptional activation domains impact coactivator binding

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Recent advances in predicting and modeling conformational ensembles of intrinsically disordered proteins (IDPs) have provided much needed insights into sequence‐ensemble relationships. It is thought that conservation of physicochemical properties, but not the exact identity or order of the amino acids, maintains IDP ensemble properties that ...
To Uyen Do, Emma J. Kraft, Garrett F. Chappell, Stuart Parnham, Rebecca B. Berlow   +4 more
wiley   +1 more source

Cryptocurrencies, Blockchain and Regulation: A Review

Lahore Journal of Economics
The evolution of money has accompanied the development of civilizations and technological innovations, leading to today’s cryptocurrencies. Cryptocurrencies have become a popular mode of payment globally because of their low cost, high-speed ...
Ayesha Afzal, Aiman Asif
doaj  

Astilbin Protects Against Ischemic Stroke by Regulating ERK1/2/CREB/p90RSK Signaling and Ferroptosis-Related SLC7A11/ACSL4/GPX4 Axis: Insights from Network Pharmacology, Multi-Omics, and Molecular Dynamics. [PDF]

Int J Mol Sci
Jin C, Zhang Y, Li B, Cheng Z, Zheng M, Dong W, Song K, Ai Y.   +7 more
europepmc   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

High sucralose exposure in early pregnancy increases the susceptibility of heart defects in mice offspring. [PDF]

iScience
Zhang Z, Yu Z, Shi H, Ding T, Shi Y, Zhao J, Cai K, Wang F.   +7 more
europepmc   +1 more source