Results 181 to 190 of about 91,942 (288)

Microglial Activation Plays a Critical Role in LPS‐Induced Contextual Fear Memory Consolidation Impairment and Blood‐Brain Barrier Disruption

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Background Accurately predicting environmental dangers is a fundamental ability for animal and human survival. Fear memory could be disrupted by various stimuli, including inflammation, which can be mimicked by lipopolysaccharide (LPS) injection. LPS, which can activate microglia and disrupt the blood‐brain barrier (BBB), can impair contextual
Jun Zheng, Linxuan Li, Xinchun Jin, Wencao Liu   +3 more
wiley   +1 more source

Metal Ions in Longgu (Fossilized Bone) as a Natural Synergistic Network for Multi‐Target Therapy in Psychiatric Disorders

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Longgu (fossilized bone) delivers a natural synergistic network of metal ions, Ca2+, Mg2+, Zn2+, Fe, Cu, and Mn2+ that collectively targets the interconnected pathologies of anxiety, depression, and insomnia. This multi‐ion system operates through coordinated mechanisms including ionostatic balance, cross‐pathway synergy, and systemic integration ...
Sun Xiujia, Li Zhan Hua, Gao Yuanze, Liu Jing, Li Li, Zhang Chao, Kumar Ganesan, Jianping Chen   +7 more
wiley   +1 more source

Dihydromyricetin Mitigates Depression-Related Memory Impairments Through Regulation of Hippocampal PKA-CREB-BDNF Pathway in Mice. [PDF]

Biology (Basel)
Wang L, Wang Y, Chen H, He Z, Long Y, Yu L, Xiao C, Zhou J, Yu X, Long Q, Shu X.   +10 more
europepmc   +1 more source

Syntaxin‐3 Regulates Tight Junction Assembly in Human Retinal Pigment Epithelium

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT The retinal pigment epithelium (RPE) consists of polarized epithelial cells, serving as a support system for photoreceptor maintenance, where the polarity is contributed by the distribution of syntaxins (STX) within the cell. STX3, a known regulator of apical trafficking in epithelial cells, was previously understood to be absent in human RPE ...
Athira Ramesh, Suganya Sivagurunathan, Navya Valavath Baburajan, Subbulakshmi Chidambaram   +3 more
wiley   +1 more source

Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice. [PDF]

Clin Transl Med
Cai S, Ma M, Zhu Y, Shi M, Dai X, Wang Y, Li M, Yu Y, Wang Y, Xu L.   +9 more
europepmc   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Isolation and Anti-Melanogenic Activity of Polycarpol from <i>Ganoderma lucidum</i> Mycelia: Expanding the Functional Potential of Cultured Mycelial Biomass. [PDF]

J Fungi (Basel)
Park CH, Lee SC, Kang RW, Park YJ.
europepmc   +1 more source

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges.
Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko Mladenov, Dimiter Avtanski, Nikola Hadzi‐Petrushev   +5 more
wiley   +1 more source

Neurogenesis and neuroplasticity activities of natural products: therapeutic potential in Alzheimer's disease. [PDF]

Front Pharmacol
Shaheen AM, Mousa MHA, Hindam MO, El-Dessouki AM, Fahim SA, Hal DM, Ahmed S, El-Shiekh RA, Khalifa HO.   +8 more
europepmc   +1 more source

GLP‐1 Receptor Agonists and Endoscopy: Understanding Gastric Stasis, Aspiration Risk, and Contemporary Peri‐Procedural Guidance

Chronic Diseases and Translational Medicine, Volume 12, Issue 3, Page 183-196, September 2026.
Pharmacological mechanisms and physiologic effects of GLP‐1 receptor agonists relevant to peri‐endoscopic risk. ABSTRACT The global increase in obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD) has led to a higher use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) among patients ...
Junaid Beig, Jason Ta, Sophie Jones, Emily Scott, Khalid Sofi, Frances Osler, Marije Jansen, Puneet Chhabra   +7 more
wiley   +1 more source