Molecular Basis and Clinical Spectrum of WNT10A‐Related Oligodontia
Cellular Mechanism behind WNT10A phenotypes. ABSTRACT WNT10A mutations, a major genetic determinant of dental agenesis and ectodermal dysplasia, exert profound effects on craniofacial development. Although classified as rare disorders, these mutations account for more than half of oligodontia cases, reflecting their critical role.
Perennes Elise +5 more
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Activation of the TGR5/cAMP/PKA/CREB axis in cholangiocytes mediates epithelial-mesenchymal transition and fibrosis in hepatolithiasis. [PDF]
Tang D, Yang J, Shi X, Gu X, Zhao L.
europepmc +1 more source
Ossifying spindled and epithelioid tumour (OSET) can show unusual morphologic features, including minimal or absent peripheral ossification, eosinophil‐rich stroma, increased mitotic activity (≥5 mitotic figures per 10 high‐power fields), and necrosis.
Rayan M Sibira +9 more
wiley +1 more source
Cang-Ai Volatile Oil Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-like Symptoms in Rats by Regulating NT/Trk Signaling Pathway. [PDF]
Shi M +7 more
europepmc +1 more source
Propranolol reinstates mitochondrial dynamics and synaptic memory pathways through CaMKII/CREB-BDNF/ PKMζ cascades in an AD-like rat model. [PDF]
Pinky +6 more
europepmc +1 more source
ABSTRACT Liver fibrosis is a shared pathological phenotype of chronic liver diseases of diverse etiologies, including viral hepatitis, alcohol‐associated liver disease and metabolic dysfunction–associated steatohepatitis (MASH), as well as cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis, and may ...
Kiminori Kimura, Michinori Kohara
wiley +1 more source
Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis. [PDF]
Farjami Z, Akbarin MM.
europepmc +1 more source
GR‐A knockin mice were generated that express the classic full‐length glucocorticoid receptor (GR‐A) but lack the highly conserved translational isoforms GR‐B, GR‐C1, GR‐C2, GR‐C3, GR‐D1, GR‐D2, and GR‐D3 that have progressively shorter N‐terminal transactivation domains (NTDs).
Robert H. Oakley +8 more
wiley +1 more source
Tetrahedral framework nucleic acids carrying tranexamic acid to alleviate ultraviolet B-induced skin pigmentation. [PDF]
Cai T +8 more
europepmc +1 more source
Deer antler polypeptides promote osteogenesis for fracture healing via activating neurosensory PGE2/EP4/p-CREB axis. [PDF]
He Y +8 more
europepmc +1 more source

