Results 211 to 220 of about 139,153 (288)

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Gene expression regulation by Ca²⁺ signaling: an updated systematic review. [PDF]

Cell Mol Biol Lett
Zou M, Wang H, Zeng X, Zhang X.
europepmc   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Molecular Mechanisms of Transcription Factors with Dual Activator and Repressor Functions. [PDF]

Mol Cell Biol
Dong J, Guertin MJ.
europepmc   +1 more source

Association of glucagon‐like peptide‐1 receptor agonist use with clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 766-780, May 2026.
This TriNetX (US, 2016–2023) study compared clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes treated with GLP‐1 receptor agonists vs DPP4 inhibitors. ABSTRACT Objectives To evaluate whether glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are associated with improved survival and renal outcomes in patients with ...
Yu‐Ting Yu, Ying Chun Lee, Yu‐Wei Fang, Wen‐Hui Hsieh, Ming‐Hsien Tsai   +4 more
wiley   +1 more source

GJB2 drives LUAD progression in part via cAMP-mediated M2 macrophage polarization through the PKA-CREB pathway. [PDF]

Respir Res
Liu Y, Liu G, Mei J, Li J, Si J, Kang Y, Jin J.   +6 more
europepmc   +1 more source

Fetuin‐b Mediates Lipid Overload‐Induced Hepatic Lipid Accumulation in Large Yellow Croaker (Larimichthys crocea)

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Schematic of the mechanism of fetuin‐b mediated high‐fat diet‐induced hepatic steatosis in Larimichthys crocea. Lipid overload triggers C/EBPα‐mediated fetuin‐b upregulation. Fetuin‐b drives hepatic lipid accumulation by reprogramming lipid metabolism and inhibiting Plin2 ubiquitination to stabilize lipid droplets, identifying it as a potential ...
Yanan Shen, Qiuchi Chen, Zengqi Zhao, Qiang Chen, Yuhang Tang, Fan Chen, Tingting Hao, Jianlong Du, Qinghui Ai   +8 more
wiley   +1 more source

Amygdala-hippocampus circuit regulates stress coping via mGluR5-dependent BDNF signaling. [PDF]

Mol Cells
Kim TE, Choi TY, Koo JW, Kim J.
europepmc   +1 more source

Astrocytic CREB regulates transcriptomic, neuronal, and behavioral responses to cocaine. [PDF]

Sci Adv
Holt LM, Minier-Toribio A, Futamura R, Browne CJ, Martínez-Rivera FJ, Markovic T, Gyles TM, Yeh SY, Parise EM, Rivera M, Brenner C, Yim YY, Kondev V, Estill M, Yan S, Keane E, Labanca A, Rojas G, Shen L, Dong Y, Nestler EJ.   +20 more
europepmc   +1 more source

Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells. [PDF]

Int J Immunopathol Pharmacol
Yang F, Liang P, Guo H, Yan W, Wang G, Tang X, Liang Z.   +6 more
europepmc   +1 more source