Results 231 to 240 of about 87,086 (298)

Massage Regulates Brain Plasticity in Chronic Sciatic Nerve Compression Injury Rats: A Study Based on Resting‐State Functional Magnetic Resonance Imaging

Brain and Behavior, Volume 16, Issue 6, June 2026.
Resting‐state functional magnetic resonance imaging analysis of chronic constriction injury rats after massage therapy. ABSTRACT Background Neuropathic pain (NP) is associated with maladaptive functional reorganization of the brain, yet the central mechanisms through which massage therapy exerts its analgesic effects remain poorly understood.
Lanting Huang, Xuekun Zhou, Lechun Chen, Chenyu Wang, Hao Wang, Huanzhen Zhang, Changzheng Jiang, Shuijin Chen, Jingjing Jiang, Qiangwen Xie, Zhigang Lin   +10 more
wiley   +1 more source

Baclofen Inhibits Glioma Proliferation via the MEK/ERK/CREB Pathway. [PDF]

Oncol Res
Zhou B, Shen L, Lu X.
europepmc   +1 more source

Synergistic Antitumor Activity of HAT Inhibitor A485 and XPO1 Inhibitor KPT8602 in Multiple Myeloma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Multiple myeloma (MM) remains the second most common hematologic malignancy, necessitating the identification of novel therapeutic targets. MM is characterized by a distinct epigenetic landscape driven by aberrant chromatin activation and super‐enhancer addiction.
Hong Xu, Wenqi Wu, Yanan Jiang, Jinhuan Wang, Yixin Zhai, Zhigang Zhao   +5 more
wiley   +1 more source

The Antidepressant Amitriptyline Upregulates ERK1/2 Signaling and Inhibits Rho-Mediated Responses Induced by Lysophosphatidic Acid in Astroglial Cells. [PDF]

Int J Mol Sci
Olianas MC, Dedoni S, Onali P.
europepmc   +1 more source

SIRT1: Protean roles at the nexus of health, disease, and therapeutics

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
SIRT1 serves as a central regulator linking metabolism, stress responses, and disease. It influences diverse processes, including transcriptional and posttranscriptional gene expression and protein activity, inflammation, mitochondrial function, and cell survival, through the deacetylation of multiple protein targets. While SIRT1 often plays protective
Brahim Chaqour
wiley   +1 more source

Effects of increasing intranuclear calcium levels via MCU inhibition on mouse and human PSC-derived cardiomyocyte differentiation and maturation. [PDF]

Stem Cells Transl Med
Seo HJ, Kim JY, Cho HJ, Lee JE, Bang SB, Jeon M, Lee HA, Shin YJ, Yang HM, Kim HS.   +9 more
europepmc   +1 more source

Vitamin D receptor signaling in inflammatory senescence–associated skin aging: Mechanisms and therapeutic potentials

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Vitamin D receptor (VDR) signaling is implicated in inflammatory senescence‐associated skin aging, a growing health concern in aging populations where cellular senescence and chronic inflammation converge to create complex pathophysiological conditions.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Histamine H₁ Receptor-Mediated CREB Phosphorylation via G_q Protein Signaling and Arrestin Modulation. [PDF]

Pharmaceuticals (Basel)
Ogami R, Michinaga S, Iiboshi Y, Ogawa Y, Hishinuma S.   +4 more
europepmc   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Kelulut honey (<i>Heterotrigona itama</i>) as a multi-target neuroprotective strategy against bisphenol A-induced neurotoxicity. [PDF]

Toxicol Rep
Azmi SK, Ali NF, Siran R.
europepmc   +1 more source