Results 221 to 230 of about 91,942 (288)

Corticosteroid Receptor Modulation in the Dorsal Striatum Prevents Morphine‐Induced Place Preference and Reduction in Dopamine Transporter (DAT) Immunoreactivity in Rats

Addiction Biology, Volume 31, Issue 9, September 2026.
Intra‐dorsal striatal corticosterone attenuated morphine‐induced CPP. GR and MR antagonists also attenuated morphine‐induced CPP. Morphine reduced DAT immunoreactivity, an effect prevented by CORT and antagonists. Distinct corticosteroid manipulations converged on similar reward and DAT outcomes.
Payman Raise‐Abdullahi, Fatemeh Rezamohammadi, Mehrnoush Rahmani, Abbas Ali Vafaei, Roghayeh Pakdel, Hamed Rashidipour, Ali Rashidy‐Pour   +6 more
wiley   +1 more source

Cannabidiol enhances tamoxifen efficacy via CREB-mediated suppression of ERα signaling in ER-positive breast cancer cells. [PDF]

Cell Biosci
Kim BG, Kim O, Lee DY, Kim BR, Kim DY, Namgung Y, Bong JW, Kang S, Lee SI, Oh SC.   +9 more
europepmc   +1 more source

Clinical outcomes of the chemo‐free approach in relapsed/refractory follicular lymphoma: A network meta‐analysis

British Journal of Haematology, Volume 209, Issue 3, Page 874-886, September 2026.
Graphical overview of the network meta‐analysis (NMA) evaluating chemo‐free approaches for relapsed/refractory follicular lymphoma (R/R FL). Epcoritamab plus rituximab (R2) achieved the highest cumulative ranking probability (SUCRA) across efficacy end‐points but increases the risk of predictable toxicity over anti‐CD20 monotherapy.
Daniele Caracciolo, Maria Rita Lombardo, Gianluca Reitano, Cristina Napoli, Lucia Fiorillo, Chiara Callerame, Mario Garritano, Alessio Bulotta, Maha Munir, Giulia Pensabene, Emiliano Barbieri, Alberto Bavieri, Pierfrancesco Tassone, Pierosandro Tagliaferri, Stefano Luminari   +14 more
wiley   +1 more source

Glycodeoxycholic and deoxycholic bile acids impair recognition and spatial memory in adult mice, and reduce central CREB-BDNF signaling and cytokine expression with neuroanatomical specificity. [PDF]

Gut Microbes
Garcia A, Trivedi D, Anthony DC, Swann JR, Burnet PWJ.   +4 more
europepmc   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

Gut microbiota and uric acid excretion signaling in pathogenesis of hyperuricemia and acute gouty arthritis. [PDF]

iScience
Wang M, Yang R, An H, Chen B, Chen Q, Chen Z, Li M, Yang F, Xiao Y, Chen P, Guo J, Su Y, Huang B.   +12 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Targeting GluN2B-containing N-methyl-D-aspartic acid receptors to alleviate excitotoxic secondary brain injury after traumatic brain injury. [PDF]

Neurotherapeutics
Lv Y, Yang M, Niu F, Zhuang Y, Liu W, Gao G, Liu B, Tian R.   +7 more
europepmc   +1 more source