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▪ Abstract The cAMP responsive element binding protein (CREB) is a nuclear protein that modulates the transcription of genes with cAMP responsive elements in their promoters. Increases in the concentration of either calcium or cAMP can trigger the phosphorylation and activation of CREB.
A J, Silva +3 more
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CREB, neurogenesis and depression
AbstractThe transcription factor CREB has been implicated in signalling pathways relevant for pathogenesis and therapy of depression. CREB is upregulated and activated in the hippocampus by chronic antidepressant treatment, similarly as neurogenesis.
P. Gass, M.A. Riva
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CREB-Mediated Transcriptional Control
Critical Reviews in Eukaryotic Gene Expression, 1999cAMP-response-element-binding protein, CREB, is a 43-kDa leucine zipper transcription factor identified and cloned via the study of cAMP-regulated genes. In the last decade, numerous studies have contributed much to our understanding of CREB structure, function, and CREB-mediated transcription.
Ourania Andrisani
exaly +3 more sources
Frontiers in Bioscience, 2004
Programmed cell death (PCD) is major concept in neurobiology and transcription factors are pivotal in switching on the nerve cell death program. More recently, the transcriptional control of programmed cell life (PCL) is beginning to be understood. This work began in studies of the activation of the CREB transcription factor in stroke models where it ...
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Programmed cell death (PCD) is major concept in neurobiology and transcription factors are pivotal in switching on the nerve cell death program. More recently, the transcriptional control of programmed cell life (PCL) is beginning to be understood. This work began in studies of the activation of the CREB transcription factor in stroke models where it ...
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Optogenetic Inhibitor of the Transcription Factor CREB [PDF]
SummaryCurrent approaches for optogenetic control of transcription do not mimic the activity of endogenous transcription factors, which act at numerous sites in the genome in a complex interplay with other factors.
Sheena Ann Josselyn, Andrew Woolley
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CREB-1 and CREB-2 immunoreactivity in the rat brain
Brain Research, 1996This study is focused to learn about the cellular localization of transcription factors binding to the cAMP response element-CREBs-in the brain of normal rats and in animals subjected to excitotoxic cell damage. For this purpose, CREB-1 and CREB-2 immunoreactivity is examined in the developing and adult rat brain under physiological conditions, and ...
I, Ferrer +6 more
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Trends in Neurosciences, 2005
The transcription factor CREB is best known for its involvement in learning and memory. However, emerging evidence suggests that CREB activity has very different roles--sometimes beneficial, sometimes detrimental--depending on the brain region involved.
William A, Carlezon +2 more
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The transcription factor CREB is best known for its involvement in learning and memory. However, emerging evidence suggests that CREB activity has very different roles--sometimes beneficial, sometimes detrimental--depending on the brain region involved.
William A, Carlezon +2 more
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Cellular and Molecular Life Sciences (CMLS), 1999
The prevailing hypothesis for the formation of long-term memory (LTM) is that introduction of a memory item alters the pattern of existing neuronal connectivity to form a neuronal network that will subserve the information for long-term storage. Modulation of synaptic efficacy is induced by changes in synaptic transmission within selected synapses or ...
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The prevailing hypothesis for the formation of long-term memory (LTM) is that introduction of a memory item alters the pattern of existing neuronal connectivity to form a neuronal network that will subserve the information for long-term storage. Modulation of synaptic efficacy is induced by changes in synaptic transmission within selected synapses or ...
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2002
Abstract In technical terms, which will be explained below, CREB, CAMP-response element-binding protein, is a protein that modulates the transcription of genes with CAMP-response elements in their promoters. CREB is one of the most commonly used acronyms in neurobiology these days, and also one of the few words in the jargon of molecular
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Abstract In technical terms, which will be explained below, CREB, CAMP-response element-binding protein, is a protein that modulates the transcription of genes with CAMP-response elements in their promoters. CREB is one of the most commonly used acronyms in neurobiology these days, and also one of the few words in the jargon of molecular
openaire +1 more source

