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CREB-1 and CREB-2 immunoreactivity in the rat brain
Brain Research, 1996This study is focused to learn about the cellular localization of transcription factors binding to the cAMP response element-CREBs-in the brain of normal rats and in animals subjected to excitotoxic cell damage. For this purpose, CREB-1 and CREB-2 immunoreactivity is examined in the developing and adult rat brain under physiological conditions, and ...
I, Ferrer +6 more
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2002
Abstract In technical terms, which will be explained below, CREB, CAMP-response element-binding protein, is a protein that modulates the transcription of genes with CAMP-response elements in their promoters. CREB is one of the most commonly used acronyms in neurobiology these days, and also one of the few words in the jargon of molecular
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Abstract In technical terms, which will be explained below, CREB, CAMP-response element-binding protein, is a protein that modulates the transcription of genes with CAMP-response elements in their promoters. CREB is one of the most commonly used acronyms in neurobiology these days, and also one of the few words in the jargon of molecular
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Frontiers in Bioscience, 2004
Programmed cell death (PCD) is major concept in neurobiology and transcription factors are pivotal in switching on the nerve cell death program. More recently, the transcriptional control of programmed cell life (PCL) is beginning to be understood. This work began in studies of the activation of the CREB transcription factor in stroke models where it ...
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Programmed cell death (PCD) is major concept in neurobiology and transcription factors are pivotal in switching on the nerve cell death program. More recently, the transcriptional control of programmed cell life (PCL) is beginning to be understood. This work began in studies of the activation of the CREB transcription factor in stroke models where it ...
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Trends in Neurosciences, 2005
The transcription factor CREB is best known for its involvement in learning and memory. However, emerging evidence suggests that CREB activity has very different roles--sometimes beneficial, sometimes detrimental--depending on the brain region involved.
William A, Carlezon +2 more
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The transcription factor CREB is best known for its involvement in learning and memory. However, emerging evidence suggests that CREB activity has very different roles--sometimes beneficial, sometimes detrimental--depending on the brain region involved.
William A, Carlezon +2 more
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CREB-Mediated Transcriptional Control
Critical Reviews in Eukaryotic Gene Expression, 1999cAMP-response-element-binding protein, CREB, is a 43-kDa leucine zipper transcription factor identified and cloned via the study of cAMP-regulated genes. In the last decade, numerous studies have contributed much to our understanding of CREB structure, function, and CREB-mediated transcription.
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CREB Signaling-Timing Is Everything
Science Signaling, 2001Depolarization of neurons can lead to changes in gene expression that are important for such processes as synaptic plasticity, neuronal differentiation, and apoptosis. Impey and Goodman discuss some of the opposing models for how gene transcription in response to neuronal activity and elevations in intracellular calcium concentration is regulated.
S, Impey, R H, Goodman
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CREB Activation and Ischaemic Preconditioning
Cardiovascular Drugs and Therapy, 2008Previous studies from our laboratory showed that activation of p38 MAPK is one of the triggers of ischaemic preconditioning. The signalling events downstream of p38 MAPK and their links to the putative final effectors of preconditioning are not clear.
E, Marais, S, Genade, A, Lochner
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Targeting CREB signalling in neurogenesis
Expert Opinion on Therapeutic Targets, 2010Expansion and ultimately homeostasis of neural cell number is exquisitely regulated by molecular genetic networks operating in neural stem and progenitor cells (NSPCs) and in the neural stem cell niche during embryogenesis and in the adult brain. Transcription factors are crucial in orchestrating the correct cell-specific and temporal expression of all
Mantamadiotis, T
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Science's STKE, 2007
Although growth factors and stress stimulate the phosphorylation of cAMP response element-binding protein (CREB), these signals do not trigger the expression of the same genes as those activated by stimuli that activate cAMP signaling. Two groups (Ravnskjaer et al .
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Although growth factors and stress stimulate the phosphorylation of cAMP response element-binding protein (CREB), these signals do not trigger the expression of the same genes as those activated by stimuli that activate cAMP signaling. Two groups (Ravnskjaer et al .
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[Transcriptional regulation by CREB and proteins of CREB family].
Sheng li ke xue jin zhan [Progress in physiology], 1998CREB (cAMP-responsive element binding protein), which can be activated after phosphorylation by protein kinase A, plays an important role in cAMP-induced gene expression. Several recent studies have suggested that a co-activator designated as CREB binding protein (CBP) is crucial in mediating the transcriptional activity of CREB.
J H, Tian, X M, Wang, J S, Han
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