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The CREB family of transcription activators
Current Biology, 1992A diverse family of transcription factors bind to the cAMP-response elements found in a variety of mammalian and viral gene promoters. One of the members of this family, CREB, is being intensively studied so as to elucidate the mechanisms by which second messenger signal transduction pathways act to positively and negatively regulate transcription.
P K, Brindle, M R, Montminy
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Regulation of Cocaine Reward by CREB
Science, 1998Cocaine regulates the transcription factor CREB (adenosine 3′,5′-monophosphate response element binding protein) in rat nucleus accumbens, a brain region that is important for addiction. Overexpression of CREB in this region decreases the rewarding effects of cocaine and makes low doses of the drug aversive.
W A, Carlezon +8 more
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CREB Signaling-Timing Is Everything
Science Signaling, 2001Depolarization of neurons can lead to changes in gene expression that are important for such processes as synaptic plasticity, neuronal differentiation, and apoptosis. Impey and Goodman discuss some of the opposing models for how gene transcription in response to neuronal activity and elevations in intracellular calcium concentration is regulated.
S, Impey, R H, Goodman
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CREB Activation and Ischaemic Preconditioning
Cardiovascular Drugs and Therapy, 2008Previous studies from our laboratory showed that activation of p38 MAPK is one of the triggers of ischaemic preconditioning. The signalling events downstream of p38 MAPK and their links to the putative final effectors of preconditioning are not clear.
E, Marais, S, Genade, A, Lochner
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Targeting CREB signalling in neurogenesis
Expert Opinion on Therapeutic Targets, 2010Expansion and ultimately homeostasis of neural cell number is exquisitely regulated by molecular genetic networks operating in neural stem and progenitor cells (NSPCs) and in the neural stem cell niche during embryogenesis and in the adult brain. Transcription factors are crucial in orchestrating the correct cell-specific and temporal expression of all
Mantamadiotis, T
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CREB and the discovery of cognitive enhancers
Journal of Molecular Neuroscience, 2002In the past few years, a series of molecular-genetic, biochemical, cellular and behavioral studies in fruit flies, sea slugs and mice have confirmed a long-standing notion that long-term memory formation depends on the synthesis of new proteins. Experiments focused on the cAMP-responsive transcription factor, CREB, have established that neural activity-
Roderick, Scott +4 more
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Hyperphosphorylation of CREB in human dopaminergic neurons
NeuroReport, 2013The neurotoxin, 6-hydroxy dopamine (6-OHDA)-induced oxidative stress causes alterations in intracellular signalling events and activates cellular and molecular mechanisms leading to the degeneration of the dopamine-containing neurons (DCNs). The cyclic-AMP response element-binding protein (CREB) modulates the transcription of mitochondrial and nuclear ...
Bushra Y, Ahmed +7 more
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[Transcriptional regulation by CREB and proteins of CREB family].
Sheng li ke xue jin zhan [Progress in physiology], 1998CREB (cAMP-responsive element binding protein), which can be activated after phosphorylation by protein kinase A, plays an important role in cAMP-induced gene expression. Several recent studies have suggested that a co-activator designated as CREB binding protein (CBP) is crucial in mediating the transcriptional activity of CREB.
J H, Tian, X M, Wang, J S, Han
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