Results 31 to 40 of about 5,843 (265)

Damage and hardening evolution characteristics of sandstone under multilevel creep–fatigue loading

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
During the operation of artificial underground structures, the surrounding rock experiences fatigue and creep damage caused by several types of disturbances under long-term constant loading.
Zhang Bichuan, Liang Yunpei, Zou Quanle, Ning Yanhao, Kong Fanjie   +4 more
doaj   +1 more source

Bone creep-fatigue damage accumulation

Journal of Biomechanics, 1989
Creep and fatigue tests were performed on human femoral cortical bone and the results were compared to a cumulative damage model for bone fracture. Fatigue tests in tension, compression, and reversed loading with a tensile mean stress were conducted at 2 Hz and 0.02 Hz.
W E, Caler, D R, Carter
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

Numerical analysis of triaxial creep-fatigue interaction of rock salt

Journal of Rock Mechanics and Geotechnical Engineering
This study investigates the creep-fatigue interaction characteristics of rock salt under triaxial conditions. Utilizing PFC2D to conduct creep-fatigue simulation tests on rock salt under various confining pressures and stress intervals, the research ...
Louis Ngai Yuen Wong, Kai Zhao
doaj   +1 more source

Mechanical Strength and Fatigue Fracture Analysis on Al-Zn-Mg Alloy with the Influence of Creep Aging Process

Advances in Materials Science and Engineering, 2021
The Al-Zn-Mg alloy comes under the aluminium alloy; it possesses good capability of age hardening and superior strength in contrast to other alloys. The numbers of creep aging experiments are conducted with the support of different temperature levels ...
Muruganantham Ponnusamy, Bhanu Pratap Pulla, T. Sathish, Sivakumar Karthikeyan, S. Ravindran, Balachandra Pattanaik, Ram Subbiah   +6 more
doaj   +1 more source

Design and Assessment for Creep-Fatigue and Creep-Fatigue Crack Growth

Volume 1B: Codes and Standards, 2016
Creep-fatigue assessments require inputs for both creep damage and fatigue damage. Then these damage terms are combined using some form of interaction diagram to enable estimation of the creep-fatigue life. Similarly, creep-fatigue crack growth assessments need separate calculations of creep crack growth, fatigue crack growth and again possibly some ...
openaire   +1 more source

Trajectories of Physical Function in Canadian Children With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective We describe trajectories of physical function in children newly diagnosed with juvenile idiopathic arthritis (JIA) and identify trajectories with persisting functional impairments and associated baseline characteristics. Methods We included patients enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry ...
Clare Cunningham, Meghan McPherson, Lillian Lim, Roberta A. Berard, Matthew Berkowitz, Jean‐Philippe Proulx‐Gauthier, Brian M. Feldman, Nicole Johnson, Dax G. Rumsey, Heinrike Schmeling, Lori B. Tucker, Thomas Loughin, Kristin M. Houghton, Jaime Guzman, for the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry Investigators, David A. Cabral, Gaëlle Chédeville, Ciarán M. Duffy, Kerstin Gerhold, Jaime Guzman, Linda Hiraki, Adam M. Huber, Heinrike Schmeling, Natalie J. Shiff, Lori B. Tucker, Julie Barsalou, Daniah Basodan, Michelle Batthish, Roberta A. Berard, Nicholas Blanchette, Gilles Boire, Roxana Bolaria, Alessandra Bruns, David A. Cabral, Sarah Campillo, Tania Cellucci, Mercedes Chan, Gaëlle Chédeville, Amieleena Chhabra, Julie Couture, Paul Dancey, Jean‐Jacques De Bruycker, Erkan Demirkaya, Muhammed Dhalla, Ciarán M. Duffy, Talal El Tal, Tommy Gerschman, Jaime Guzman, Liane Heale, Julie Herrington, Kristin M. Houghton, Adan M. Huber, Andrea Human, Nicole Johnson, Roman Jurencak, Bianca Lang, Claire LeBlanc, Lillian Lim, Lily S. H. Lim, Nadia Luca, Jeanine McColl, Tara McGrath, Tamara McMillan, Megan McPherson, Paivi Miettunen, Kimberly Morishita, Honyan Ng, Jonathan Park, Jean‐Philippe Proulx‐Gauthier, Johannes Roth, Evelyn Rozenblyum, Dax G. Rumsey, Heinrike Schmeling, Rosie Scuccimarri, Gordon Soon, Rebeka Stevenson, Elizabeth Stringer, Herman Tam, Lori B. Tucker, Marinka Twilt, Ruud H. J. Verstegen, Karen Watanabe Duffy   +81 more
wiley   +1 more source

Impact of creep-fatigue interaction on divertor tungsten under high heat flux

Nuclear Materials and Energy, 2023
High heat flux as 20 MW m−2 during stationary operation can be foreseen in future fusion devices, leading to recrystallization and thermal creep in tungsten targets. Both recrystallization and thermal creep impact would play significant roles in service.
Yu-Zhong Jin, Hao Wang, Xiang Liu, You-Yun Lian, Fan Feng, Jian-bao Wang, Zong-jian Chai, Jiu-Peng Song, Xu-ru Duan   +8 more
doaj   +1 more source