Results 41 to 50 of about 12,587 (316)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source
Advances in Materials Science and Engineering, 2021 The Al-Zn-Mg alloy comes under the aluminium alloy; it possesses good capability of age hardening and superior strength in contrast to other alloys. The numbers of creep aging experiments are conducted with the support of different temperature levels ...
Muruganantham Ponnusamy +6 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Numerical analysis of triaxial creep-fatigue interaction of rock salt
Journal of Rock Mechanics and Geotechnical EngineeringThis study investigates the creep-fatigue interaction characteristics of rock salt under triaxial conditions. Utilizing PFC2D to conduct creep-fatigue simulation tests on rock salt under various confining pressures and stress intervals, the research ...
Louis Ngai Yuen Wong, Kai Zhao
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Impact of creep-fatigue interaction on divertor tungsten under high heat flux
Nuclear Materials and Energy, 2023 High heat flux as 20 MW m−2 during stationary operation can be foreseen in future fusion devices, leading to recrystallization and thermal creep in tungsten targets. Both recrystallization and thermal creep impact would play significant roles in service.
Yu-Zhong Jin +8 more
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ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2021 LE-9 rocket engine for H3 launch vehicle is being developed for realizing high performance, low cost and high reliability. Thermal fatigue life prediction on a combustion chamber structure with multiple cooling holes is important for design of rocket ...
Tatsuya KAMEYAMA +6 more
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A parametric study on creep-fatigue strength of welded joints using the linear matching method [PDF]
, 2013 This paper presents a parametric study on creep-fatigue strength of the steel AISI type 316N(L) weldments of types 1 and 2 according to R5 Vol. 2/3 Procedure classification at 550◦C.
Chen, Haofeng, Gorash, Yevgen
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Creep–fatigue Interaction Testing [PDF]
, 2001 Fatigue fives in metals are nominally time independent below 0.5 T(sub Melt). At higher temperatures, fatigue lives are altered due to time-dependent, thermally activated creep. Conversely, creep rates are altered by super. imposed fatigue loading. Creep and fatigue generally interact synergistically to reduce material lifetime.
openaire +1 more source
Trajectories of Physical Function in Canadian Children with Juvenile Idiopathic Arthritis
Arthritis Care &Research, Accepted Article.Objectives We describe trajectories of physical function in children newly diagnosed with juvenile idiopathic arthritis (JIA) and identify trajectories with persisting functional impairments and associated baseline characteristics. Methods We included patients enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry ...
Clare Cunningham +14 more
wiley +1 more source