Results 31 to 40 of about 129,917 (285)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Creep-fatigue life assessment of cruciform weldments using the linear matching method [PDF]

, 2013
This paper presents a creep-fatigue life assessment of a cruciform weldment made of the steel AISI type 316N(L) and subjected to reversed bending and cyclic dwells at 550C using the Linear Matching Method (LMM) and considering different weld zones.
Chen, Haofeng, Gorash, Yevgen
core   +4 more sources

Viscoelastic plastic creep constitutive model based on energy conservation law and strain energy theory

Scientific Reports
On the basis of the law of conservation of energy, the three stages of rock creep are analyzed. The reasons for the difficulty in studying the accelerated creep stage of rocks using the traditional creep model are expounded.
Di Zhou, Xiangjin Tian, Shuguang Zhang, Wang Zeng, Minye Zhang, Yanchao Feng, Wenbo Liu, Xiang Huang, Mingzhuo Fan, Ye Sun   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microscopic time‐dependent mechanical behavior of shale derived from nanoindentation

Deep Underground Science and Engineering
Understanding the microscopic time‐dependent mechanical behavior of shale is critical for assessing macroscopic creep and engineering applications.
Cunbao Li, Shilei Zhong, Heping Xie, Changtai Zhou, Jianjun Hu   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Time-dependentness of Creep Parameter Degradation and Variable Parameter Creep Model

工程科学与技术, 2021
In order to better study the creep properties of rocks under different conditions, the rock triaxial creep tests were conducted using the MTS812.02 test system. Based on the rock rheological mechanics, damage theory and the characteristic analysis of the
Wenbo LIU, Shuguang ZHANG, Boyi SUN
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Review of Creep Cavitation and Rupture of Low Cr Alloy and its Weldment [PDF]

, 2013
This paper presents a review of creep cavitation and rupture of low Cr alloy and its weldment, particular in the heat-affected zone (HAZ). Creep damage is one of the serious problems for the high temperature industry.
Xu, Qiang, Short, Michael, Short, Michael; id_orcid, Xu, Qihua, Xu, Qi Hua, Pang, Yong Xin, Pang, Yongxin   +6 more
core   +1 more source

Development of Advanced Creep Damage Constitutive Equations for Low CR Alloy Under Long-Term Service [PDF]

Low Cr alloys are mostly utilized in structural components such as steam pipes, turbine generators and reactor pumps operating at high temperatures from 400℃ to 700℃ in nuclear power plants.
Xu, Qihua
core   +3 more sources