Results 41 to 50 of about 34,050 (268)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Effect of Time and Stress on Creep Damage Characteristics of Cement-Based Materials

Buildings
In the realm of daily life, ensuring the safety of building structures and civil engineering projects remains a paramount research focus. The creep properties of materials significantly influence their long-term loading process.
Yifan Zhang, Tianxiang Sun, Mingze Qin, Dongxu Zhang, Nan Qin, Yongyan Wang   +5 more
doaj   +1 more source

Time-scale effect of the creep model parameters and particle flow simulation of sandstone with a single crack

Yantu gongcheng xuebao, 2019
The creep deformation behaviors of the hard rocks in deep high-stress environment, especially for the fractured hard rocks, cannot be neglected. To investigate the long-term creep deformation behaviors and the creep model for the fractured hard rock, the
HU Bo 1, YANG Sheng-qi 1,2, XU Peng 3, TIAN Wen-ling 1
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Research on Creep Model of Roadway Surrounding Rock Based on Variable Creep Parameters

Meikuang Anquan, 2020
In order to study the creep behavior of surrounding rock of Huaying Coal Mine in Sichuan under different confining pressure characteristics, the triaxial creep test of sandstone was carried out by TAW-2000 test system.
LIU Changming, ZHANG Hong
doaj   +1 more source

A Comparative Study on Creep Behavior of Wood Flour-Polypropylene Composite, Medium Density Fiberboard (MDF) and Particleboard [PDF]

علوم و تکنولوژی پلیمر, 2009
The creep/recovery behavior of wood flour-polypropylene was compared with medium density fiberboard (MDF) and particleboard. For this purpose, wood flour-polypropylene composites (with and without compatibilizer)were manufactured by using a laboratory ...
J. Nikrai, S. Kazemi Najafi, Gh. Ebrahimi   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Creep constitutive model of strain energy density considering the whole process of creep deformation.

PLoS ONE
Aiming at the problem that the traditional creep model is difficult to reflect the characteristics of accelerated creep stage of rock, the influence of stress state on accelerated creep is fully considered, and a constitutive model which can describe ...
Yuemei Li
doaj   +1 more source