Results 61 to 70 of about 129,917 (285)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Thermal creep effects of aluminum alloy cladding on the irradiation-induced mechanical behavior in U–10Mo/Al monolithic fuel plates

Nuclear Engineering and Technology, 2020
Three-dimensional finite element simulations are implemented for the in-pile thermo-mechanical behavior in U–Mo/Al monolithic fuel plates with different thermal creep rates of cladding involved. The numerical results indicate that the thickness increment
Xiaobin Jian, Shurong Ding
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Creep Model and Experimental Verification of Sandstone under the Coupled Effect of Chemical Corrosion and Temperature

Applied Sciences
The Nishihara creep model is an extremely effective method in the field of sandstone creep model research. However, the Nishihara creep model curve for sandstone under the marine environment (the coupled effect of chemical corrosion and temperature) does
Xia Xiu, Yong Wang, Ye Zhou, Geng Niu, Shijun Zhao, Degong Chang   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Study on Creep Characteristics and Constitutive Relation of Fractured Rock Mass

Shock and Vibration, 2020
In order to effectively describe the whole creep process of fractured rock mass, triaxial unloading creep tests were carried out on prefractured coal samples using constant axial pressure and graded unloading confining pressure, and the axial and lateral
Maotong Li, Kesheng Li, Deng Zhang, Chuanxiao Liu, Depeng Ma   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Probability-creep strain-time curve and size effect of creep strain measurement

Materials Research Express
In this study, compressive creep tests were at first conducted on different types of specimens of Ti-6Al-4V titanium alloy by different loading methods. The results indicate that the loading method and specimen type generally have a significant impact on
Yiyun Guo, Han Wu, Jianghua Li, Chengqi Sun   +3 more
doaj   +1 more source