Results 31 to 40 of about 8,649 (263)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

An anisotropic creep-permeability model for rock

Yantu gongcheng xuebao
The service life of underground engineering is so long that the creep deformation of the surrounding rock can be intensified in the water environment. The permeability shows an anisotropic trend under the three-dimension stresses.
LIU Xueying 1, 2 , YU Jin 1 , ZHOU Xianqi 3, YAO Wei 3, REN Chonghong 1, CAI Yanyan 1
doaj   +1 more source

Study on the Creep Behaviors of Interactive Marine-Terrestrial Deposit Soils

Advances in Civil Engineering, 2019
The interactive marine-terrestrial (IMT) deposit soils were formed in the complex depositional environment; their mechanical properties are different from the other deposits.
Zhen Yan, Gang Li, Jinli Zhang, Rui Zhang   +3 more
doaj   +1 more source

Using Maxwell’s Theory to model and quantify the fracture evolution of cyclothymic deposition phosphate rock

Frontiers in Earth Science, 2023
The evolution and stability of fracturing in the cyclothymic deposition of phosphate rocks are strongly affected by the viscoelasticity and structural form of the rock-forming minerals.
Deng Pan, Deng Pan, Yuanyou Xia, Dianji Zhang, Xuyong Chen, Qiaoyun Wu, Manqing Lin, Zhangqiong Wang, Jun Pan   +8 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Experimental Study on Creep Characteristics and Mechanisms of Wenzhou Soft Soil

Journal of Marine Science and Engineering
This study investigates the creep behavior of Wenzhou marine soft soil through 1D and triaxial creep tests, revealing that the secondary consolidation coefficient initially increases then stabilizes with stress level, decreases with OCR, increases with ...
Yongwei Chen, Yi Shi, Junju Qiu, Wei Qin, Zhijin Zhou, Guoxiang Peng, Kun Lou, Yuanyuan Liu   +7 more
doaj   +1 more source

Creep Coefficient for Self-Compacting Concrete (SCC)

International Journal of Computational and Experimental Science and Engineering
With the development of construction technology, self-compacting concrete hasstarted to be widely used in the construction of buildings. The specific properties of selfcompacting concrete have made it particularly useful for concreting the structuralelements of high-rise buildings.
Hajdar SADIKU, Mazllum KAMBERI, Gazmend NAFEZI   +2 more
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source