Results 41 to 50 of about 8,649 (263)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Microscopic mechanism study of the creep properties of soil based on the energy scale method
Frontiers in Materials, 2023 The study of the creep properties of soils is of great importance for the management of future settlements and the safe use of buildings. However, starting from the micro level is an effective way to explore the creep mechanism of soft soil.
Jie Yuan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Creep characteristics and constitutive model construction of offshore soft soils
Journal of Traffic and Transportation Engineering (English ed. Online)The main objective of this study was to investigate creep characteristics and construct a suitable constitutive model for soft soils in offshore areas. Soft soil samples were obtained to evaluate the physical and mechanical properties.
Hainian Wang +5 more
doaj +1 more source
Experimental Study of the Nonlinear Behaviour of Deep-Sea Mooring Polyester Fibre Ropes
Polish Maritime Research, 2023 Mooring ropes are essential components of ships and offshore floating structures and they are subjected to cyclic axial loads. This study investigates the evolution of the full-cycle stiffness of fibre polyester ropes under long-term static and dynamic ...
Zhang He +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A novel nonlinear creep model based on damage characteristics of mudstone strength parameters.
PLoS ONE, 2021 Mudstone interlayer is a weak layer in rock engineering. When it is subjected to continuous stress higher than its damage threshold, due to the dislocation of particles in mudstone crystals and the expansion of cracks, mudstone strength is gradually ...
Bin Hu +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source